IP Library › Granted Patent US 12,311,145
Granted Patent B2
US 12,311,145 · App. 17/149,419 · Granted May 27, 2025

Infusion devices and related rescue detection methods

Inventors: Neha J. Parikh (West Hills, CA); Anirban Roy (Agoura Hills, CA); Benyamin Grosman (Winnetka, CA); Rebecca K. Gottlieb (Culver City, CA); Di Wu (Glendale, CA)
Assignee: MEDTRONIC MINIMED, INC.
A61M5/1723A61M5/14244A61M5/14248A61M5/168A61M5/172A61M2205/502A61M2205/52A61M2230/005A61M2230/201
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Quick Facts
Patent No.
US 12,311,145
App. No.
17/149,419
Granted
May 27, 2025
Kind
B2
Abstract

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption.

Claims (50)

1. A system for operating an infusion device to deliver fluid to a body of a user, the device comprising:

one or more processors; and

one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause the one or more processors to:

after detecting a measurement value for a physiological condition that violates a first threshold indicative of a hypoglycemic event, determine, by a control system associated with the infusion device, that a user has consumed rescue carbohydrates to mitigate the hypoglycemic event when a rate of change that is determined based on successive measurement values is greater than a second threshold, wherein the physiological condition is influenced by the delivery of fluid to the body of the user from the infusion device; and

in response to determining that the user has consumed rescue carbohydrates to mitigate the hypoglycemic event, limit, by the control system, delivery of the fluid from the infusion device.

2. The system of claim 1 , wherein the second threshold represents a change in the measurement value over the successive measurement values indicative of the user having consumed rescue carbohydrates.

3. The system of claim 1 , wherein the measurement value is one of a plurality of measurement values, and wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause the one or more processors to:

detect, by the control system, an absence of hypoglycemia based on one or more of the measurement values after limiting the delivery of the fluid; and

in response to detecting the absence of hypoglycemia, restore, by the control system, the delivery of the fluid.

4. The system of claim 1 , wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause the one or more processors to:

operate the infusion device to deliver a variable rate of infusion based at least in part on a target value for the physiological condition,

wherein limiting the delivery of the fluid comprises temporarily capping the variable rate.

5. The system of claim 1 , wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause the one or more processors to:

prior to detecting the measurement value for the physiological condition that violates the first threshold, operate the infusion device in a closed-loop mode having a first maximum rate of infusion,

wherein limiting the delivery of the fluid comprises operating the infusion device to deliver the fluid in a rescue mode, wherein a second maximum rate of infusion associated with the rescue mode is less than the first maximum rate of infusion associated with the closed-loop mode.

6. The system of claim 5 , wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause the one or more processors to:

detect, by the control system, an exit condition while operating the infusion device to deliver the fluid in the rescue mode; and

in response to detecting the exit condition, operate the infusion device to deliver the fluid in the closed-loop mode.

7. The system of claim 1 , wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause the one or more processors to:

after limiting the delivery of the fluid, restore, by the control system, the delivery of the fluid in response to a meal indication.

8. The system of claim 1 , wherein limiting delivery of the fluid from the infusion device comprises:

determining, by the control system, a fluid dosage generated in accordance with a closed-loop operating mode of the infusion device; and

scaling, by the control system, the determined fluid dosage based on a ratio of a limited maximum rate of infusion associated with a rescue mode to a normal closed-loop maximum rate of infusion.

9. The system of claim 8 , wherein the rescue mode has a maximum dosage associated therewith that is less than a corresponding maximum dosage associated with the closed-loop operating mode.

10. The system of claim 8 , wherein the rescue mode comprises a safe mode having one or more of a lower maximum rate of infusion than the closed-loop operating mode or control parameter coefficients adjusted for a slower response time than the closed-loop operating mode.

11. A processor-implemented method for operating an infusion device to deliver fluid to a body of a user, the method comprising:

after detecting a measurement value for a physiological condition that violates a first threshold indicative of a hypoglycemic event, determining that a user has consumed rescue carbohydrates to mitigate the hypoglycemic event when a rate of change that is determined based on successive measurement values is greater than a second threshold, wherein the physiological condition is influenced by the delivery of fluid to the body of the user from the infusion device; and

in response to determining that the user has consumed rescue carbohydrates to mitigate the hypoglycemic event, limiting delivery of the fluid from the infusion device.

12. The method of claim 11 , wherein the second threshold represents a change in the measurement value over the successive measurement values indicative of the user having consumed rescue carbohydrates.

13. The method of claim 11 , wherein the measurement value is one of a plurality of measurement values, the method further comprising:

detecting an absence of hypoglycemia based on one or more of the measurement values after limiting the delivery of the fluid; and

in response to detecting the absence of hypoglycemia, restoring the delivery of the fluid.

14. The method of claim 11 , the method further comprising:

operating the infusion device to deliver a variable rate of infusion based at least in part on a target value for the physiological condition,

wherein limiting the delivery of the fluid comprises limiting the delivery of the fluid comprises temporarily capping the variable rate.

15. The method of claim 11 , further comprising:

prior to detecting the measurement value for the physiological condition that violates the first threshold, operating the infusion device in a closed-loop mode having a first maximum rate of infusion,

wherein limiting the delivery of the fluid comprises operating the infusion device to deliver the fluid in a rescue mode, wherein a second maximum rate of infusion associated with the rescue mode is less than the first maximum rate of infusion associated with the closed-loop mode.

16. The method of claim 15 , further comprising:

detecting an exit condition while operating the infusion device to deliver the fluid in the rescue mode; and

in response to detecting the exit condition, operating the infusion device to deliver the fluid in the closed-loop mode.

17. The method of claim 11 , further comprising:

after limiting the delivery of the fluid, restoring the delivery of the fluid in response to a meal indication.

18. The method of claim 11 , wherein limiting delivery of the fluid from the infusion device comprises:

determining a fluid dosage generated in accordance with a closed-loop operating mode of the infusion device;

scaling the determined fluid dosage based on a ratio of a limited maximum rate of infusion associated with a rescue mode to a normal closed-loop maximum rate of infusion.

19. The method of claim 18 , wherein the rescue mode has a maximum dosage associated therewith that is less than a corresponding maximum dosage associated with the closed-loop operating mode.

20. One or more non-transitory processor-readable storage media storing instructions which, when executed by one or more processors, cause performance of:

after detecting, by a control system associated with an infusion device, a measurement value for a physiological condition that violates a first threshold indicative of a hypoglycemic event, determining that a user has consumed rescue carbohydrates to mitigate the hypoglycemic event when a rate of change that is determined based on successive measurement values is greater than a second threshold, wherein the physiological condition is influenced by the delivery of fluid to a body of the user from the infusion device; and

in response to determining that the user has consumed rescue carbohydrates to mitigate the hypoglycemic event, limiting reducing, by the control system, delivery of the fluid from the infusion device.

Assignments (2)
SECURITY INTEREST Recorded Jan 16, 2026
From: MEDTRONIC MINIMED, INC.; COMPANION MEDICAL, INC.
To: CITIBANK, N.A.
Reel/Frame 074394/0237 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2021
From: PARIKH, NEHA J.; ROY, ANIRBAN; GROSMAN, BENYAMIN; GOTTLIEB, REBECCA K.; WU, DI
To: MEDTRONIC MINIMED, INC.
Reel/Frame 054925/0473 →
Continuity (4)
Continuation 16162277 · Oct 16, 2018
Continuation 15096156 · Apr 11, 2016
Provisional Application 62234471 · Sep 29, 2015
Related Publication 20210128834A1 · May 6, 2021
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