OSTEOSTIMULATING ELASTOMERIC BONE FILLING COMPOSITIONS
A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.
1 . A method of treating a bone defect, the method comprising:
molding a bone filling composite and placing the bone filling composite in the bone defect;
wherein the bone filling composite comprises a bone filler comprising microparticles of at least one elastomeric material, a carrier material comprising a poly(glycerol sebacate) resin, and a biologic medium.
2 . The method of claim 1 , wherein the biologic medium is selected from the group consisting of blood, serum, demineralized bone matrix, bone chips, bone morphogenic proteins, and combinations thereof.
3 . The method of claim 1 , wherein the carrier material further comprises a material selected from the group consisting of a polypeptide, a polysaccharide, a glycosaminoglycan, a hydrogel, and combinations thereof.
4 . The method of claim 1 , wherein the microparticles comprise thermoset poly(glycerol sebacate).
5 . The method of claim 1 , wherein the molding comprises mixing the bone filler, the carrier material, and the biologic medium to form the bone filling composite.
6 . The method of claim 5 , wherein the molding occurs before the placing.
7 . The method of claim 1 , wherein the molding comprises forming a sheet of the bone filling composite.
8 . A bone filling composite comprising:
a bone filler comprising microparticles of at least one elastomeric material;
a carrier material comprising a poly(glycerol sebacate) resin; and
a biologic medium.
9 . The bone filling composite of claim 8 , wherein the biologic medium is selected from the group consisting of blood, serum, demineralized bone matrix, bone chips, bone morphogenic proteins, and combinations thereof.
10 . The bone filling composite of claim 8 , wherein the carrier material further comprises a material selected from the group consisting of a polypeptide, a polysaccharide, a glycosaminoglycan, a hydrogel, and combinations thereof.
11 . The bone filling composite of claim 8 , wherein the microparticles comprise thermoset poly(glycerol sebacate).