Lubricious medical device coating with low particulates
Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
1. A medical device comprising:
a substrate; and
a first layer disposed on the substrate, the first layer comprising
polyvinylpyrrolidone derivatized with a photoreactive group;
at least one acrylamide containing copolymer selected from the group consisting of poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide] and N-Acetylated poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate; and
sodium bis(4-benzoylphenyl) phosphate (BPP).
2. The medical device of claim 1 , wherein the coating releases less than 10,000 particles greater than 10 microns in size when exposed to an aqueous environment.
3. The medical device of claim 1 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 2:1 to about 30:1 (wt./wt.).
4. The medical device of claim 1 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 8:1 to about 16:1 (wt./wt.).
5. The medical device of claim 1 , the first layer further comprising non-derivatized polyvinylpyrrolidone.
6. The medical device of claim 1 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force.
7. The medical device of claim 1 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force for at least 10 consecutive testing cycles.
8. The medical device of claim 1 , the coating exhibiting a durability of lubricity such there is less than a 30 percent increase in measured friction between the average of cycles 1-5 of testing and cycles 10-15 of testing.
9. The medical device of claim 1 , wherein the thickness of the first layer is between about 100 and 3000 nm when dry.
10. The medical device of claim 1 , wherein the photoreactive group is benzophenone.
11. The medical device of claim 1 , wherein the medical device is a balloon catheter.
12. The medical device of claim 1 , the substrate comprising a catheter shaft.
13. The medical device of claim 1 , the substrate comprising a metal or a polymer.
14. A medical device comprising:
a substrate; and
a first layer disposed on the substrate, the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group;
N-Acetylated poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate; and
sodium bis(4-benzoylphenyl) phosphate (BPP).
15. The medical device of claim 14 , wherein the coating releases less than 10,000 particles greater than 10 microns in size when exposed to an aqueous environment.
16. The medical device of claim 14 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 2:1 to about 30:1 (wt./wt.).
17. The medical device of claim 14 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 8:1 to about 16:1 (wt./wt.).
18. The medical device of claim 14 , wherein the photoreactive group is benzophenone.
19. The medical device of claim 14 , wherein the medical device is a balloon catheter.
20. The medical device of claim 14 , the substrate comprising a catheter shaft.