Nozzles for nasal drug delivery
A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
1. A method for delivering a compound to an upper olfactory region of a nasal cavity, the method comprising:
responsive to a nozzle being actuated, the nozzle positioned for intranasal delivery of the compound to a subject, wherein actuating the nozzle pressurizes a proximal end of the nozzle, the nozzle including a drug product inlet at the proximal end of the nozzle and a nozzle body defining a plurality of channels along a longitudinal axis, wherein the channels are disposed parallel to the longitudinal axis and are symmetric about a circle around the longitudinal axis:
transporting a propellant from a propellant chamber and the compound from a compound chamber through the drug product inlet, the drug product inlet configured to receive a mixture of the propellant and the compound;
transporting the mixture from the drug product inlet and through each of the plurality of channels, each of the plurality of channels having a proximal end and a distal end, the proximal end of each of the plurality of channels configured to receive the mixture, the distal end of each of the plurality of channels having an outlet orifice exiting to the nasal cavity; and
releasing the mixture from the outlet orifices of each of the plurality of channels directly into the nasal cavity, wherein once exited, the mixture forms a plume having a width of 5 degrees or less to enable the plume to reach the upper olfactory region of a nasal cavity.
2. The method of claim 1 , wherein each of the plurality of channels is a circular, tube-shaped channel.
3. The method of claim 1 , wherein the plume has a deposition width of 2.18 millimeters or less at a distance of 4 centimeters relative to the outlet orifices.
4. The method of claim 1 , wherein the plume has a deposition width of 1.95 millimeters or less at a distance of 4 centimeters relative to the outlet orifices.
5. The method of claim 1 , wherein the plume has a deposition width of 1.36 millimeters or less at a distance of 4 centimeters relative to the outlet orifices.
6. The method of claim 1 , wherein the plume has a deposition width between 1.36 millimeters and 2.87 millimeters at a distance of 4 centimeters relative to the outlet orifices.
7. The method of claim 1 , wherein the compound is a liquid, a powder, a gas, or combinations thereof.
8. The method of claim 1 , wherein the nozzle comprises between four to eleven channels.
9. The method of claim 1 , wherein the nozzle and the compound chamber are of uniform construction.
10. The method of claim 1 , wherein the propellant is a liquid, a gas, or combinations thereof.
11. The method of claim 1 , wherein drug product inlet is contiguous with the proximal end of the nozzle.
12. A method for delivering a compound to an upper olfactory region of a nasal cavity, the method comprising:
responsive to a nozzle being actuated, the nozzle positioned for intranasal delivery of the compound to a subject, wherein actuating the nozzle pressurizes a proximal end of the nozzle, the nozzle including a nozzle body defining a plurality of channels and a longitudinal axis, wherein the channels are disposed parallel to the longitudinal axis and are symmetric about a circle around the longitudinal axis:
transporting a mixture of a propellant and the compound through a drug product inlet of the nozzle, the drug product inlet disposed at the proximal end of the nozzle;
transporting the mixture from the drug product inlet and through each of the plurality of channels, each of the plurality of channels having a proximal end and a distal end, the proximal end of each of the plurality of channels configured to receive the mixture, the distal end of each of the plurality of channels having an outlet orifice exiting to the nasal cavity; and
releasing the mixture from the outlet orifices of each of the plurality of channels directly into the nasal cavity, wherein the mixture exits the nozzle in a direction parallel to the longitudinal axis and forms a plume having a plume angle that does not exceed 5 degrees to enable the plume to reach the upper olfactory region of a nasal cavity.
13. The method of claim 12 , wherein each of the plurality of channels is a circular, tube-shaped channel.
14. The method of claim 12 , wherein the propellant is a liquid, a gas, or combinations thereof.
15. The method of claim 12 , wherein the plume has a deposition width between 1.36 millimeters and 2.87 millimeters at a distance of 4 centimeters relative to the outlet orifices.
16. The method of claim 12 , wherein the compound is a liquid, a powder, a gas, or combinations thereof.
17. The method of claim 12 , wherein the nozzle comprises between four to eleven channels.
18. The method of claim 12 , wherein drug product inlet is contiguous with the proximal end of the nozzle.