IP Library › Granted Patent US 11,505,550
Granted Patent B2
US 11,505,550 · App. 17/164,428 · Granted Nov 22, 2022

ADO-resistant cysteamine analogs and uses thereof

Inventors: Todd C. Zankel (San Francisco, CA); John Unitt (Nottingham, GB); Timothy Phillips (Nottingham, GB); Benoit Gourdet (Nottingham, GB); Lorna Duffy (Nottingham, GB)
Assignee: HORIZON ORPHAN LLC
C07D471/08A61K31/145A61K31/397A61K31/40A61K31/4402A61K31/445A61K31/4409A61K31/4465C07C323/25C07C323/26C07C323/30C07D205/04C07D207/08C07D211/54C07D211/60C07D213/32C07D213/70C07D223/06C07D295/088C07D451/04C07C2601/04
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Quick Facts
Patent No.
US 11,505,550
App. No.
17/164,428
Granted
Nov 22, 2022
Kind
B2
Abstract

The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.

Claims (5)

1. A compound having the following structure or a disulfide thereof:

wherein R 1 is C 1-5 alkyl; and

R 3 , R 4 , R 5 , R 7 , and R 8 are independently selected from the group consisting of H and C 1-5 alkyl.

2. A compound having the following structure or a disulfide thereof:

wherein R 1 , R 3 , R 4 , R 5 , R 6 , and R 7 are independently selected from the group consisting of H and C 1-5 alkyl.

Continuity (4)
Division 15201969 · Jul 5, 2016
Provisional Application 62387337 · Dec 23, 2015
Provisional Application 62187939 · Jul 2, 2015
Related Publication 20220024920A1 · Jan 27, 2022