SAMPLE CARTRIDGES
A versatile cartridge is disclosed especially designed to collect and store varying samples, such as urine or fecal matter, and hold the sample while the sample is processed by a centrifuge, and to hold the sample while the sample is examined from a top or bottom view by an optical system within an instrument or analyzer.
1 . A cartridge, comprising:
an elongated body having a top side, and a bottom side;
an elongated central chamber within the body and having a first end and a second end spanning a substantial length of the body;
a first film covering a top portion of central chamber;
a second film covering a bottom portion of the central chamber;
a fill port positioned on the top side of the body and adapted to introduce fluid into the first end of the central chamber; and
a hydrophobic filter positioned at the second end of the chamber.
2 . The cartridge in claim 1 , further comprising a peel off transparent protective film covering the first film.
3 . The cartridge in claim 1 , wherein the central chamber holds a minimum of 250 uL of sample.
4 . The cartridge in claim 3 , wherein the central chamber is at least 62.5 mm long, 4 mm wide, and 1 mm deep.
5 . The cartridge in claim 1 , wherein the first film and the second film are both transparent to be able to view and image any sample within the chamber from the top portion or the bottom portion.
6 . The cartridge in claim 5 , wherein a viewing area is a minimum of 250 mm 2 .
7 . The cartridge in claim 1 , further comprising a tethered cap for connecting to the fill port and sealing any sample within the central chamber.
8 . The cartridge in claim 1 , wherein the hydrophobic filter is adapted to allow air to escape the chamber while a sample is being loaded and provides a slight positive pressure feedback to a user indicating the chamber is fully filled.
9 . The cartridge in claim 1 , further geometric features adapted to provide capability for interfacing with an instrument to align the cartridge consistently, retain the cartridge during centrifuge, move the cartridge through the instrument for processing, and hold the cartridge flat during optical scanning.
10 . The cartridge in claim 9 , wherein the geometric features include optical Z hold down pads to control cartridge flatness when under microscope.
11 . The cartridge in claim 9 , wherein the geometric features include a poke yoke skirt to prevent the cartridge from being inserted backwards into the instrument.
12 . The cartridge in claim 9 , wherein the geometric features include a push pillar which allows an instrument stage to move the cartridge into and out of the centrifuge and through the instrument.
13 . The cartridge in claim 9 , wherein the geometric features include a X-datum spring to control lateral movement and hold against an optical datum during inspection.
14 . The cartridge in claim 9 , wherein the geometric features include a centrifuge Z hold down springs which retain the cartridge when being spun in the centrifuge.
15 . The cartridge in claim 9 , further comprising web and ribs for longitudinal bracing.
16 . The cartridge in claim 1 , further comprising laser etched microscopic features on the first film or second film for improved optical calibration and object identification accuracy.
17 . A cartridge, comprising:
an elongated body having a top side, and a bottom side;
an elongated central chamber within the body and having a first end and a second end spanning a substantial length of the body;
a first transparent film covering a top portion of central chamber;
a second transparent film covering a bottom portion of the central chamber;
a fill port positioned on the top side of the body and adapted to introduce fluid into the first end of the central chamber; and
a hydrophobic filter positioned at the second end of the chamber.
18 . The cartridge in claim 17 , wherein the hydrophilic filter is adapted to allow air to escape the chamber while a sample is being loaded and provides a slight positive pressure feedback to a user indicating the chamber is fully filled.
19 . The cartridge in claim 17 , further geometric features adapted to provide capability for interfacing with an instrument to align the cartridge consistently, retain the cartridge during centrifuge, move the cartridge through the instrument for processing, and hold the cartridge flat during optical scanning.
20 . A cartridge, comprising:
an elongated body having a top side, and a bottom side;
an elongated central chamber within the body and having a first end and a second end spanning a substantial length of the body;
a first transparent film covering a top portion of central chamber;
a second transparent film covering a bottom portion of the central chamber;
a fill port positioned on the top side of the body and adapted to introduce fluid into the first end of the central chamber;
a hydrophobic filter positioned at the second end of the chamber, wherein the hydrophobic filter is adapted to allow air to escape the chamber while a sample is being loaded and provides a slight positive pressure feedback to a user indicating the chamber is fully filled; and
geometric features adapted to provide capability for interfacing with an instrument to align the cartridge consistently, retain the cartridge during centrifuge, move the cartridge through the instrument for processing, and hold the cartridge flat during optical scanning.