Cardiovascular Prostheses
Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include particulate structures that are formed from an ECM/ECM-mimicking composition. The ECM/ECM-mimicking composition consists of a mixture of particulate structures including particulate structures formed from acellular ECM derived from a mammalian tissue source and particulate structures formed from poly(glycerol sebacate) (PGS) and everolimus.
1 . A cardiovascular prosthesis, consisting of:
an ECM/ECM-mimicking composition consisting of a first plurality of first particulate structures and a second plurality of second particulate structures,
said first plurality of first particulate structures consisting of acellular extracellular matrix (ECM) from a mammalian tissue source,
said second plurality of second particulate structures consisting of poly(glycerol sebacate) (PGS) and everolimus,
said first plurality of first particulate structures and said second plurality of second particulate structures, when disposed proximate damaged cardiovascular tissue, adapted to jointly induce remodeling of said damaged cardiovascular tissue,
said second plurality of second particulate structures, when disposed proximate said damaged cardiovascular tissue, further adapted to suppress hyperplasia.