IP Library Granted Patent US 11,898,948
Granted Patent B2
US 11,898,948 · App. 17/182,166 · Granted Feb 13, 2024

Facing and quality control in microtomy

Inventors: Partha P. Mitra (New York, NY); Janak Sewkarran (New York, NY); Baris Yagci (New York, NY); Jerry R. Pinto (New York, NY)
Assignee: Clarapath, Inc.
G01N1/36G01B11/22G01N1/06G01N1/286G01N1/312G01N21/6456G01N21/6486G01N35/00603G01N35/00613G01N35/00732G06T7/0014G06T7/521G01N2001/2873G01N2035/00039G01N2035/00861G01N2035/00881G06T2207/30024
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Quick Facts
Patent No.
US 11,898,948
App. No.
17/182,166
Filed
Feb 22, 2021
Granted
Feb 13, 2024
Kind
B2
Art Unit
1796
USPC
436/43
Abstract

The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.

Claims (42)

1. A system comprising:

an information reader configured to read identifying data associated with a tissue block;

a microtome configured to cut one or more tissue sections from the tissue block;

one or more slides for receiving the one or more tissue sections;

a visualization system in communication with a processor programmed to generate a comparison between a tissue sample in one or more first images of the tissue block and one or more tissue samples in one or more second images of the one or more tissue sections; and

a printer configured to receive the identifying data and print, based on the comparison and after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one or more tissue sections on the one or more slides with the tissue block.

2. The system of claim 1 , further comprising a transfer medium configured to transfer the one or more tissue sections from the tissue block to the one or more slides.

3. The system of claim 2 , wherein the transfer medium includes markings indicative of the identifying data associated with the tissue block, the markings being configured to associate the one or more tissue sections with the tissue block.

4. The system of claim 2 , further comprising a transfer medium marking device to mark the transfer medium with markings indicative of the identifying data associated with the tissue block, the markings are configured to associate the one or more tissue sections with the tissue block.

5. The system of claim 1 , wherein the one or more second images are of the one or more tissue sections after being cut by the microtome, and

wherein the one or more tissue sections are on a transfer medium configured to transfer the one or more tissue sections from the tissue block, or the one or more tissue sections on the one or more slides.

6. The system of claim 1 , wherein the comparison is based on a size, shape and outline of the tissue sample in the one or more tissue sections.

7. The system of claim 1 , wherein the visualization system is programmed to read the one or more labels on the one or more slides and confirm their association with the identifying data on the tissue block.

8. The system of claim 1 , wherein the printer prints the one or more labels individually for the one or more tissue sections.

9. A system comprising:

an information reader configured to read identifying data from a tissue block;

a printer; and

a processor programmed to:

receive the identifying data,

generate a comparison between a tissue sample in one or more first images of the tissue block and one or more tissue samples in one or more second images of one or more tissue sections cut from the tissue block, and

cause the printer to print, based on the comparison, one or more labels for the one or more tissue sections cut from the tissue block, the one or more labels comprising information associating the one or more tissue sections with the identifying data from the tissue block.

10. The system of claim 9 , further comprising a transfer medium configured to transfer the one or more tissue sections to one or more slides.

11. The system of claim 10 , wherein the transfer medium includes markings indicative of the identifying data associated with the tissue block, the markings being configured to associate the one or more tissue sections with the tissue block.

12. The system of claim 10 , further comprising a transfer medium marking device to mark the transfer medium with markings indicative of the identifying data associated with the tissue block, the markings being configured to associate the one or more tissue sections with the tissue block.

13. The system of claim 9 , wherein the one or more second images are of the one or more tissue sections after being cut by a microtome,

wherein the one or more tissue sections are on a transfer medium configured to transfer the one or more tissue sections from the tissue block, or the one or more tissue sections on one or more slides.

14. The system of claim 9 , wherein the processor is further programmed to cause a microtome to cut the one or more tissue sections.

15. The system of claim 9 , wherein the comparison is based on one or more of a size, shape and outline of the tissue sample in the one or more tissue sections.

16. The system of claim 9 , wherein the processor is further programmed to read the one or more labels and confirm their association with the identifying data on the tissue block.

17. A system comprising:

at least one processor coupled to memory, the at least one processor programmed to:

receive, from an information reader, identifying data associated with a tissue block;

generate a comparison between a tissue sample in one or more first images of the tissue block and one or more tissue samples in one or more second images of one or more tissue sections; and

cause a printer to print, based on the comparison, one or more labels for one or more slides that receive the one or more tissue sections, the one or more labels comprising identifying data associated with the tissue block to associate the one or more tissue sections with the tissue block.

18. The system of claim 17 , wherein the one or more second images are of the one or more tissue sections after being cut by a microtome, and

wherein the one or more tissue sections are on a transfer medium configured to transfer the one or more tissue sections on the one or more slides.

19. A system comprising:

an information reader configured to read identifying data associated with one or more tissue blocks;

a microtome configured to cut one or more tissue sections from the one or more tissue blocks;

one or more slides for receiving the one or more tissue sections;

a visualization system in communication with a processor programmed to generate a comparison between (i) one or more first tissue samples in one or more first images of the one or more tissue blocks and (ii) one or more second tissue samples in one or more second images of the one or more tissue sections; and

a printer configured to receive the identifying data and print, based on the comparison, one or more labels for the one or more slides, the one or more labels comprising information associating each of the one or more tissue sections on the one or more slides with one tissue block of the one or more tissue blocks.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2021
From: MITRA, PARTHA P.; SEWKARRAN, JANAK; YAGCI, BARIS; PINTO, JERRY R.
To: CLARAPATH, INC.
Reel/Frame 057802/0417 →
Continuity (6)
Provisional Application 63134399 · Jan 6, 2021
Provisional Application 62980194 · Feb 22, 2020
Provisional Application 62980203 · Feb 22, 2020
Provisional Application 62980201 · Feb 22, 2020
Provisional Application 62980202 · Feb 22, 2020
Related Publication 20210262905A1 · Aug 26, 2021
Cited By (8)
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