Methods of modulating pericytes
The present disclosure is directed to methods of modulating pericytes in subjects in need thereof.
1. A method of promoting new vessel formation in a subject in need thereof, the method comprising administering an adrenal corticotropin treatment, wherein VCAM- 1 expression and angiopoietin- 2 expression is increased after the administering.
2. The method of claim 1 , wherein the adrenal corticotropin treatment comprises a repository corticotropin injection (RCI).
3. The method of claim 2 , wherein the repository corticotropin injection is a naturally sourced complex mixture of adrenocorticotropic hormone analogs and other pituitary peptides.
4. The method of claim 3 , wherein the respository corticotropin injection comprises N-25 deamidated porcine ACTH (1-39).
5. The method of claim 1 , wherein the adrenal corticotropin treatment is administered at a daily dose of 30-150 U/m2 over a 2-3 week period.
6. The method of claim 5 , wherein the daily dose is gradually tapered over a 2 week period.
7. The method of claim 5 , wherein peak VCAM- 1 expression and angiopoietin- 2 expression is after 3 weeks of administration.
8. A method of promoting new vessel formation in a subject in need thereof, the method comprising administering an adrenal corticotropin treatment to a subject in need thereof, wherein VCAM- 1 expression and angiopoietin- 2 expression is increased following 3 weeks of administering the adrenal corticotropin.
9. The method of claim 8 , further comprising isolating a microvessel from the treated subject.
10. The method of claim 9 , further comprising staining the isolated microvessel from the treated subject.
11. The method of claim 10 , further comprising counting an increased number of vessels per square mm from the isolated microvessel.
12. The method of claim 8 , wherein maximum angiopoietin- 2 expression is reached after 3 weeks of administering the adrenal corticotropin.