Zirconium phosphate disinfection recharging and conditioning
The invention relates to systems and methods for disinfecting, recharging, and conditioning zirconium phosphate in a reusable sorbent module. The systems and methods provide for reuse of a zirconium phosphate sorbent module after dialysis.
1. A method of recharging zirconium phosphate in a zirconium phosphate sorbent module, comprising the steps of:
flowing a brine solution through the zirconium phosphate sorbent module; and
flowing a disinfectant solution through the zirconium phosphate sorbent module after flowing the brine solution through the zirconium phosphate sorbent module.
2. The method of claim 1 , further comprising the step of flowing water through the zirconium phosphate sorbent module after the steps of flowing disinfectant solution and brine solution through the zirconium phosphate sorbent module.
3. The method of claim 1 , wherein the disinfectant solution is a peracetic acid solution and the brine solution contains acetic acid, sodium acetate, and sodium chloride.
4. The method of claim 3 , wherein the brine solution contains between 0 and 5.0 M sodium chloride, between 0.1 M and 2.0 M sodium acetate, and between 0.1 and 2.0 M acetic acid.
5. The method of claim 3 , wherein the disinfectant solution contains between 0.1 and 3.0 wt % peracetic acid or between 0.1 and 3.0 wt % peracetic acid and between 0.1 to 15 wt % acetic acid.
6. The method of claim 1 , wherein the the disinfectant solution and the brine solution are maintained at room temperature while flowing the the disinfectant solution and the brine solution through the zirconium phosphate sorbent module.
7. The method of claim 1 , wherein either or both of the disinfectant solution and the brine solution is maintained at room temperature for a set period of time, and then heated for a set period of time.
8. The method of claim 1 , wherein the step of flowing the disinfectant solution through the zirconium phosphate sorbent module comprises flowing a concentrated disinfectant solution and water to a static mixer to generate a dilute disinfectant solution; and flowing the dilute disinfectant solution through the zirconium phosphate sorbent module.
9. The method of claim 1 , wherein the step of flowing a brine solution through the zirconium phosphate sorbent module comprises flowing a concentrated brine solution and water to a static mixer to generate a dilute brine solution; and flowing the dilute brine solution through the zirconium phosphate sorbent module.
10. The method of claim 1 , further comprising the step of heating the brine solution to a temperature of between 70° C. and 100° C. prior to flowing the brine solution through the zirconium phosphate sorbent module.
11. The method of claim 1 , further comprising the step of rinsing the zirconium phosphate sorbent module with water prior to flowing the disinfectant solution through the zirconium phosphate sorbent module.
12. The method of claim 1 , further comprising the step of holding the disinfectant solution in the zirconium phosphate sorbent module.
13. The method of claim 12 , wherein the disinfectant solution is held in the zirconium phosphate sorbent module for between 0 and 30 minutes, between 5 and 10 minutes, between 5 and 15 minutes, between 10 and 20 minutes, between 15 and 30 minutes or between 20 and 30 minutes.
14. The method of claim 12 , further comprising the step of flowing disinfectant solution through the zirconium phosphate sorbent module at a flow rate of between 0 and 20 mL/min while holding the disinfectant solution in the zirconium phosphate sorbent module.
15. The method of claim 12 , further comprising the step of intermittently flowing fluid through the zirconium phosphate sorbent module while holding the disinfectant solution in the zirconium phosphate sorbent module.
16. The method of claim 2 , wherein the brine solution, the water, and the disinfectant solution are flowed through the zirconium phosphate sorbent module in a direction opposite to a flow direction during therapy.