Personalized medical adjudication and treatment system
Computer implemented systems and methods for adjudication of treatments and prescriptions for a patient are provided. The method may comprise receiving a request to approve a medical request for administering a treatment to a patient; accessing a database of genetic information to determine genetic information of the patient; comparing the genetic information of the patient against a database of pharmacogenetic information in view of the medical request; and providing a response to the medical request, the response including one or more of administering the treatment to the patient, or offering an alternate treatment for the patient.
1. A method comprising:
generating, using one or more processors and in response to receiving a request to approve a medical request for administering clopidogrel to a patient, a first database query to obtain at least one of a gene variant of the patient or a genetic disposition of a population of persons to whom the patient is genetically related;
generating, using the one or more processors, a second database query to obtain blood clot formation risks of the patient from a database of personal clinical variable information;
comparing, using the one or more processors, at least one of the gene variant of the patient or the genetic disposition of the population of persons against a database of pharmacogenetic information in view of the medical request for administering clopidogrel to the patient;
comparing, using the one or more processors, the blood clot formation risks of the patient against the database of personal clinical variable information in view of the medical request for administering clopidogrel to the patient, the database of personal clinical variable information including blood clot formation risks of persons having a stent in a cardiac vessel; and
administrating clopidogrel to the patient in response to determining that clopidogrel is compatible with genetic attributes of the patient determined based on the comparing the at least one of the gene variant or the genetic disposition of the population of persons against the database of pharmacogenetic information and based on the comparing of the blood clot formation risks against the database of personal clinical variable information.
2. The method of claim 1 , wherein the request is processed by a claim processing system with access to a database of claims history for the patient.
3. The method of claim 1 , wherein the at least one of gene variants or the genetic disposition of the population of persons of the patient is provided by a third party vendor.
4. The method of claim 1 , wherein the gene variant comprises at least one of a single nucleotide polymorphisms (SNP) or a deletion.
5. The method of claim 4 , wherein the SNP is at least one of a missense mutation or a nonsense mutation.
6. The method of claim 1 , wherein the genetic disposition of the population of persons to whom the patient is genetically related comprises data about at least one of renal function, liver function, nationality, ethnicity, or race.
7. The method of claim 1 , wherein the database of personal clinical variable information comprises information about at least one of:
disease diagnosis including comparative information of drug-disease interactions,
body surface area including comparative information of drug doses,
body mass including comparative information of drug doses, or
drugs impacted by smoking induced enzyme production.
8. The method of claim 1 , wherein the database of personal clinical variable information comprises information about publicly available demographic data associated with at least one of general transportation costs, food costs, or patient-provided demographic data to compare to affordability of prescribed medical treatment.
9. The method of claim 1 , wherein the gene variant of the patient comprises an insertion.
10. The method of claim 1 , wherein the gene variant of the patient comprises at least one of a duplication, a frameshift mutation, or a repeat expansion.
11. The method of claim 1 , wherein the database of pharmacogenetic information comprises comparative information indicating the clopidogrel may be ineffective based on the at least one of gene variants or the genetic disposition of the population of persons.
12. The method of claim 1 , wherein the database of pharmacogenetic information comprises comparative information indicating the clopidogrel may cause an adverse reaction based on the at least one of gene variants or the genetic disposition of the population of persons.
13. The method of claim 1 , wherein the database of pharmacogenetic information is linked to a database of alternative solutions for the clopidogrel requested.
14. The method of claim 1 , wherein the response comprises at least one of: a warning, an alternative treatment solution, a denial of the request, an approval of the request, an alternative dosage associated with a prescribed medication as a part of the request, a suggestion for suggesting administration of a genetic test to the patient.
15. The method of claim 2 , wherein a user of the claim processing system comprises at least one of: a pharmacist, the patient, a prescribing physician, a physician assistant, or an insurance representative.
16. The method of claim 1 , further comprising continuously updating at least one of the database of pharmacogenetic information and the database of genetic information, wherein the updating comprises adding new data to the database of pharmacogenetic information based on domestic or international genetic research.