Granted Patent B2

US 12,194,214 · App. 17/187,256 · Granted Jan 14, 2025

Inventors: Martin T. Gerber (Maple Grove, MN); Christopher M. Hobot (Rogers, MN)

Assignee: Mozarc Medical US LLC

A61M1/28A61M1/1609A61M1/1619A61M1/1696A61M2205/3317A61M2205/3324A61M2205/3327A61M2205/3331A61M2205/3337A61M2205/3368A61M2205/50A61M2205/502A61M2205/52A61M2205/702

Abstract

Claims (39)

1. A system comprising:

a peritoneal dialysis cycler having either an effluent line or a combined infusion and effluent line;

at least one solute concentration sensor in communication with the effluent line or combined infusion and effluent line; and

a processor,

wherein the processor is programmed to determine a concentration of at least one solute in an effluent from a patient based on data from the at least one solute concentration sensor.

2. The system of claim 1 , wherein the processor is programmed to determine a change in concentration of the at least one solute in a peritoneal dialysate during a dwell time based on data from the at least one solute concentration sensor.

3. The system of claim 1 , wherein the at least one solute comprises glucose or dextrose.

4. The system of claim 1 , wherein the at least one solute concentration sensor is a refractive index sensor.

5. The system of claim 1 , wherein the processor is programmed to determine a membrane transfer efficiency based on a change in concentration of the at least one solute.

6. The system of claim 1 , wherein the processor is programmed to divert peritoneal dialysate from the patient to the at least one solute concentration sensor at multiple times during a dwell period.

7. The system of claim 1 , wherein the at least one solute concentration sensor is positioned in a sampling flow path fluidly connected to the effluent line or combined infusion and effluent line.

8. The system of claim 7 , further comprising a peritoneal dialysate generation flow path fluidly connected to an infusion line or the combined infusion and effluent line;

wherein the peritoneal dialysate generation flow path comprises one or more concentrate sources and a water source; and

wherein the peritoneal dialysate generation flow path is fluidly connected to the sampling flow path.

9. The system of claim 8 , wherein the processor is programmed to determine a concentration of at least one solute in a generated peritoneal dialysate from the peritoneal dialysate generation flow path.

10. The system of claim 9 , wherein the at least one solute in the generated peritoneal dialysate comprises an osmotic agent.

11. The system of claim 9 , wherein the at least one solute in the generated peritoneal dialysate comprises glucose or dextrose.

12. The system of claim 9 , wherein the processor is programmed to determine a change in concentration of the at least one solute based on the concentration of the at least one solute in the generated peritoneal dialysate and the concentration of the at least one solute in the effluent from the patient.

13. The system of claim 1 , wherein the at least one solute concentration sensor is positioned in a sampling reservoir fluidly connected to the effluent line or combined infusion and effluent line.

14. The system of claim 13 , further comprising a peritoneal dialysate generation flow path fluidly connected to an infusion line or the combined infusion and effluent line;

wherein the peritoneal dialysate generation flow path comprises one or more concentrate sources and a water source; and

wherein the peritoneal dialysate generation flow path is fluidly connected to the sampling reservoir.

15. The system of claim 14 , wherein the processor is programmed to determine a concentration of at least one solute in a generated peritoneal dialysate from the peritoneal dialysate generation flow path.

16. The system of claim 15 , wherein the at least one solute in the generated peritoneal dialysate comprises an osmotic agent.

17. The system of claim 15 , wherein the at least one solute in the generated peritoneal dialysate comprises glucose or dextrose.

18. The system of claim 1 , further comprising at least a second sensor in communication with the effluent line or combined infusion and effluent line.

19. The system of claim 18 , wherein the second sensor is selected from a group consisting of: an ion selective electrode, a pH sensor, a pressure sensor, a refractive index sensor, and a temperature sensor.

20. A system comprising:

a peritoneal dialysis cycler having either an effluent line or a combined infusion and effluent line;

at least one solute concentration sensor in communication with the effluent line or combined infusion and effluent line; and

a processor,

wherein the processor is programmed to determine a concentration of at least one solute in an effluent from a patient based on data from the at least one solute concentration sensor,

wherein the at least one solute comprises an osmotic agent.

21. A system comprising:

a peritoneal dialysis cycler having either an effluent line or a combined infusion and effluent line;

at least one solute concentration sensor in communication with the effluent line or combined infusion and effluent line; and

a processor,

wherein the processor is programmed to determine a concentration of at least one solute in an effluent from a patient based on data from the at least one solute concentration sensor, and

wherein the processor is programmed to determine a change in concentration of the at least one solute in a peritoneal dialysate during a dwell time based on data from the at least one solute concentration sensor.

Assignments (4)

Continuity (3)

References Cited (400)