Pharmaceutical packaging receptacle with a lubricant layer for removal of a charge
A receptacle includes an elongate barrel section defining a barrel length between an axial position p A and an axial position p B ; side walls each having an inner surface bordering an interior; a layer of a lubricant located on the inner surface; and a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls. An axial position p + is the axial position closest to p B at which the charge contacts the layer or the inner surfaces and an axial position p − is the axial position closest to p A at which the charge contacts the layer or the inner surfaces. The distance between p B and p + divided by the distance between p + and p A is in a range from 0 to 2 and a mean thickness of the layer between p A and p. is at least 10 nm.
1. A receptacle for pharmaceutical packaging, the receptacle comprising:
an elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p being determined along the axis, the elongate barrel section extending from an axial position p A to an axial position p B , the elongate barrel section defining a barrel length L B which is the distance between the axial position p A and the axial position p B ;
a first end closer to the axial position p A than to the axial position p B ;
a second end closer to the axial position p B than to the axial position p A ;
a first aperture at the first end that has a first aperture diameter;
a second aperture at the second end that has a second aperture diameter, the first aperture diameter is greater than the second aperture diameter;
a plurality of side walls extending over the elongate barrel section, the side walls each having an inner surface bordering an interior, the interior having a diameter;
a layer of a lubricant located on at least a part of the inner surface, wherein, at a given axial position p on the axis between the axial position p A and the axial position p B , a thickness of each side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p; and
a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls, an axial position p + being the axial position closest to the axial position p B at which the charge contacts the layer or the inner surfaces and an axial position p − being the axial position closest to the axial position p A at which the charge contacts the layer or the inner surfaces, a value of the distance between the axial position p B and the axial position p + divided by the distance between the axial position p + and the axial position p A is in a range from 0 to 2, a mean thickness of the layer determined between the axial position p A and the axial position p. is at least 10 nm, wherein at least one criteria is satisfied, the at least one criteria being selected from the group consisting of:
the length L B is in a range from 3 cm to 20 cm;
a mean value of the diameter of the interior determined over a range from the axial position p A to the axial position p B is in a range from 0.4 cm to 4 cm;
a mean thickness of one of the sidewalls determined over a range from the axial position p A to the axial position p B is in a range from 0.3 mm to 4.5 mm; and
the volume of the interior is in a range from 0.1 to 150 ml.
2. The receptacle of claim 1 , wherein the mean thickness of the layer determined between the axial position p A and the axial position p − is at most 300 nm.
3. The receptacle of claim 2 , wherein the mean thickness of the layer determined between the axial position p A and the axial position p − is at most 100 nm.
4. The receptacle of claim 1 , wherein a maximum thickness of the layer determined between the axial position p A and the axial position p − is at an axial position closer to the axial position p − than to the axial position p A .
5. The receptacle of claim 1 , wherein the mean thickness of the layer determined between the axial position p B and the axial position p + is at least 1.5 times the mean thickness of the layer determined between the axial position p A and the axial position p − .
6. The receptacle of claim 1 , wherein the charge comprises a halogen.
7. The receptacle of claim 6 , wherein the halogen is present in a coating of the charge.
8. The receptacle of claim 1 , wherein a maximum force required to remove the charge from the receptacle through the first aperture is not more than 10 N.
9. The receptacle of claim 8 , wherein the maximum force required to remove the charge from the receptacle through the first aperture occurs when a front of the charge is closer to the axial position p A than to the axial position p B .
10. The receptacle of claim 8 , wherein the maximum force required to remove the charge from the receptacle through the first aperture is at least 4 N.
11. The receptacle of claim 10 , wherein the maximum force required to remove the charge from the receptacle through the first aperture is not more than 7 N.
12. The receptacle of claim 1 , wherein the lubricant comprises one or more silicone oils.
13. The receptacle of claim 12 , wherein the one or more silicone oils are at least partially contained in a matrix bound to the inner surface.
14. The receptacle of claim 1 , further comprising a liquid pharmaceutical composition present in a section of the interior between the axial position p + and the axial position p B .
15. The receptacle of claim 1 , wherein a maximum thickness of the layer determined between the axial position p B and the axial position p + is at least 1.5 times a maximum thickness of the layer determined between the axial position p A and the axial position p.
16. The receptacle of claim 1 , wherein a continuous portion between the axial position p A and the axial position p − having a length of at least 50% of the length from the axial position p A and the axial position p − has a minimum thickness and a maximum thickness and a difference between the minimum thickness and the maximum thickness is at least 5 nm.
17. The receptacle of claim 16 , wherein the difference between the minimum thickness and the maximum thickness is at most 300 nm.
18. The receptacle of claim 1 , wherein the layer extends over at least 70% of the barrel length L B .
19. A process for preparing a disposal product, the process comprising:
providing a receptacle, the receptacle comprising:
an elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p being determined along the axis, the elongate barrel section extending from an axial position p A to an axial position p B , the elongate barrel section defining a barrel length L B which is the distance between p A and p B ;
a first end closer to the axial position p A than to the axial position p B ;
a second end closer to the axial position p B than to the axial position p A ;
a first aperture at the first end that has a first aperture diameter;
a second aperture at the second end that has a second aperture diameter, the first aperture diameter is greater than the second aperture diameter;
a plurality of side walls extending over the elongate barrel section, the side walls each having an inner surface bordering an interior, the interior having a diameter;
a layer of a lubricant located on at least a part of the inner surface, wherein, at a given axial position p on the axis between the axial position p A and the axial position p B , a thickness of each side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p; and
a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls, an axial position p + being the axial position closest to the axial position p B at which the charge contacts the layer or the inner surfaces and an axial position p − being the axial position closest to the axial position p A at which the charge contacts the layer or the inner surfaces, a value of the distance between the axial position p B and the axial position p + divided by the distance between the axial position p + and the axial position p A is in a range from 0 to 2, a mean thickness of the layer determined between the axial position p A and the axial position p. is at least 10 nm, wherein at least one criteria is satisfied, the at least one criteria being selected from the group consisting of:
the length L B is in a range from 3 cm to 20 cm;
a mean value of the diameter of the interior determined over a range from the axial position p A to the axial position p B is in a range from 0.4 cm to 4 cm;
a mean thickness of one of the sidewalls determined over a range from the axial position p A to the axial position p B is in a range from 0.3 mm to 4.5 mm; and
the volume of the interior is in a range from 0.1 to 150 ml; and
converting the receptacle into the disposal product.
20. A receptacle for pharmaceutical packaging, comprising:
an elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p being determined along the axis, the elongate barrel section extending from an axial position p A to an axial position p B ;
a first end closer to the axial position p A than to the axial position p B ;
a second end closer to the axial position p B than to the axial position p A ;
a first aperture at the first end that has a first aperture diameter;
a second aperture at the second end that has a second aperture diameter, the first aperture diameter is greater than the second aperture diameter;
a plurality of side walls extending over the elongate barrel section, the side walls each having an inner surface bordering an interior that defines a volume;
a layer of lubricant placed on at least a part of the inner surface; and
a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls, the charge being displaceable within the interior between the axial position p B and the axial position p A and removeable from the interior by pulling the charge out of the interior through the first aperture, a variable dynamic friction being defined between the charge and the side walls as the charge is displaced between the axial position p B and the axial position p A , the dynamic friction increasing as the charge is displaced in a first region of the interior in a direction from the axial position p B toward the axial position p A and decreasing as the charge is displaced in a second region of the interior in the direction from the axial position p B toward the axial position p A .