Methods for Detecting Analytes in Excreta in an Analytical Toilet
Described is a method to detect an analyte in an analytical toilet that includes the steps of receiving excreta in a bowl, transporting a measured sample of the excreta through a passage and bringing the sample into contact with a sensor. The sensor comprises a FET configured to interact with an analyte in the excreta. When the sample is brought into contact with the sensor, the sensor indicates the presence of the analyte by a distinct electric signal.
1 . A method to detect an analyte in an analytical toilet comprising:
receiving excreta in a bowl;
transporting a measured sample of the excreta through a passage; and
bringing the sample into contact with a sensor;
wherein the sensor comprises a FET configured to interact with an analyte in the excreta; and
wherein, when the sample is brought into contact with the sensor, the sensor indicates the presence of the analyte by a distinct electric signal.
2 . The method of claim 1 wherein a property of the electric signal is indicative of the concentration of the analyte in the sample.
3 . The method of claim 1 wherein the FET comprises a nanowire functionalized to interact with the analyte.
4 . The method of claim 3 wherein the analyte is selected from the group consisting of viruses, bacteria, DNA, RNA, proteins, nucleic acids, amino acids, peptides, polysaccharides, ions, and fragments thereof.
5 . The method of claim 1 wherein the analyte is selected from the group consisting of viruses, bacteria, DNA, RNA, proteins, nucleic acids, amino acids, peptides, polysaccharides, ions, pharmaceutical compounds, and fragments and metabolites thereof.
6 . The method of claim 1 wherein the sensor is located on a sensor element, wherein the toilet comprises a slot for receiving the sensor element, and wherein the slot provides an interface whereby, when the sensor element is inserted in the slot, the sensor is aligned with the passage and provided with electrical power and data communication.
7 . The method of claim 6 wherein the sensor element comprises microfluidic channels to transport the sample to the sensor.
8 . The method of claim 7 wherein the sensor element further comprises additional microfluidic channels to transport a cleaning fluid to the sensor.
9 . The method of claim 1 wherein the transport of the sample of excreta to the sensor is by continuous flow or segmented flow.
10 . The method of claim 9 wherein the segmented flow comprises a segment of a sample of excreta and a segment of buffer.
11 . The method of claim 10 wherein the segments are measured portions.
12 . The method of claim 1 wherein the sensor is cleaned after each time the sensor is exposed to a sample of excreta.
13 . The method of claim 1 wherein the sensor is calibrated after each time the sensor is exposed to a sample of excreta.
14 . The method of claim 1 wherein when two or more samples of excreta are tested, the resulting data undergoes statistical analysis by a processor to compile statistical data.
15 . The method of claim Error! Reference source not found, wherein the statistical data is used to generate individual trend data over time of the analyte in the excreta of a particular user.
16 . The method of claim 15 wherein the individual trend data is reported to the user to enhance health and wellness.
17 . The method of claim 15 wherein data from the sensor is used to monitor for or track a specific health and wellness condition.
18 . The method of claim 1 wherein the sensor can interact with two or more different analytes at the same time.
19 . The method of claim 1 wherein the sensor further comprises a layer that is permeable to a biomolecule.
20 . The method of claim 1 wherein if the electrical signal is not within a pre-determined range of the sensor, the sample of excreta is adjusted and re-tested until the electrical signal is within the pre-determined range of the sensor.