SURFACTANTS FOR HEALTHCARE PRODUCTS
Healthcare formulations, including, inventive surfactants, Active ingredient formulated as solids, liquids, or emulsions. The present disclosure provides formulations of healthcare products, such as: prescription drugs, over the counter drugs; minerals, herbal, and/or vitamin supplements; drugs administered in hospitals, clinics, physician's office, and places of palliative care; vaccines, tissue, organ, and cell transplants and/or grafts and/or infusions; and wound care formulations including topical ointments, lotions, cleaners, wipes, bandages, and dressings. The Active may be included in the formulations as a solute, a solvent, a particle, or an oil immiscible component of the formulation. The Active may be included in tablets, capsules, tinctures, liquids, or emulsions. Inventive healthcare formulations include formulations suitable for administration orally, topically, and/or by injection.
1 . A solid healthcare formulation, comprising:
at least one surfactant of Formula I,
wherein R 1 and R 2 may be the same or different, and may be selected from the group consisting of hydrogen and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
n is an integer from 2 to 5 (including 2 and 5);
m is an integer from 9 to 20 (including 9 and 20);
the terminal nitrogen is optionally further substituted with R 3 , wherein R 3 is selected from the group consisting of hydrogen, oxygen, hydroxyl, and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
an optional counterion associated with the compound which, if present, is selected from the group consisting of chloride, bromide, iodide, and hydroxide; and
at least one Active ingredient.
2 . The formulation according to claim 1 , wherein the at least one Active is selected from the group consisting of: a drug, a protein, a cell, a tissue, a vitamin, a supplement, and a mineral.
3 . The formulations according to claim 1 , further comprising at one or more excipients.
4 . The formulations according to claim 3 , wherein the one or more excipients are selected from the group consisting of: binders, fillers, disintegrents, salts, colorants, sweeteners, and flavorants.
5 . The formulation according to claim 1 , wherein the formulation is configured as a powder, a tablet, or a capsule.
6 . The formulation according to claim 1 , wherein the surfactant comprises at least one of 6-(dodecyloxy)-N,N,N-trimethyl-6-oxohexan-1-aminium iodide, having the following formula:
dodecyl 6-(dimethylamino)hexanoate N-oxide, having the following formula:
6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride, having the following formula:
4-((6-(dodecyloxy)-6-oxohexyl)dimethylammonio)butane-1-sulfonate, having the following formula:
6-(dodecyloxy)-6-oxohexan-1-aminium chloride, having the following formula:
and combinations thereof.
7 . A liquid formulation for healthcare, comprising:
at least one surfactant of Formula I,
wherein R 1 and R 2 may be the same or different, and may be selected from the group consisting of hydrogen and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
n is an integer from 2 to 5 (including 2 and 5);
m is an integer from 9 to 20 (including 9 and 20);
the terminal nitrogen is optionally further substituted with R 3 , wherein R 3 is selected from the group consisting of hydrogen, oxygen, hydroxyl, and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
an optional counterion associated with the compound which, if present, is selected from the group consisting of chloride, bromide, iodide, and hydroxide;
at least one Active ingredient; and
an aqueous component.
8 . The formulation according to claim 7 , further comprising a buffer.
9 . The formulation according to claim 7 , further comprising one or more of the following: a sweeter, a flavorant, a colorant, and/or a preservative.
10 . The formulation according to claim 7 , further comprising a thickener.
11 . The formulation according to claim 10 , wherein the formulation is one of the following: a drop, a paste, a salve, a lotion, or an ointment.
12 . The formulation according to claim 7 , wherein the surfactant comprises at least one of 6-(dodecyloxy)-N,N,N-trimethyl-6-oxohexan-1-aminium iodide, having the following formula:
dodecyl 6-(dimethylamino)hexanoate N-oxide, having the following formula:
6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride, having the following formula:
4-((6-(dodecyloxy)-6-oxohexyl)dimethylammonio)butane-1-sulfonate, having the following formula:
6-(dodecyloxy)-6-oxohexan-1-aminium chloride, having the following formula:
and combinations thereof.
13 . An emulsion for healthcare, comprising:
at least one surfactant of Formula I,
wherein R 1 and R 2 may be the same or different, and may be selected from the group consisting of hydrogen and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
n is an integer from 2 to 5 (including 2 and 5);
m is an integer from 9 to 20 (including 9 and 20);
the terminal nitrogen is optionally further substituted with R 3 , wherein R 3 is selected from the group consisting of hydrogen, oxygen, hydroxyl, and C 1 -C 6 alkyl, wherein the C 1 -C 6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate;
an optional counterion associated with the compound which, if present, is selected from the group consisting of chloride, bromide, iodide, and hydroxide; and
at least one Active ingredient;
an aqueous phase; and
a non-aqueous phase.
14 . The emulsion of claim 13 , further comprising a buffer.
15 . The emulsion of claim 13 , further comprising one or more of the following: a sweeter, a flavorant, a colorant, and/or a preservative.
16 . The formulation according to claim 13 , wherein the surfactant comprises at least one of 6-(dodecyloxy)-N,N,N-trimethyl-6-oxohexan-1-aminium iodide, having the following formula:
dodecyl 6-(dimethylamino)hexanoate N-oxide, having the following formula:
6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride, having the following formula:
4-((6-(dodecyloxy)-6-oxohexyl)dimethylammonio)butane-1-sulfonate, having the following formula:
6-(dodecyloxy)-6-oxohexan-1-aminium chloride, having the following formula:
and combinations thereof.