Granted Patent
B2
US 11,370,774 · App. 17/202,965 · Granted Jun 28, 2022
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
Inventors:
Pravin L. Kotian (Hoover, AL); Yarlagadda S. Babu (Birmingham, AL); Weihe Zhang (Vestavia Hills, AL); Peng-Cheng Lu (Vestavia Hills, AL); Minwan Wu (Vestavia Hills, AL); Wei Lv (Hoover, AL); Trung Xuan Nguyen (Hoover, AL); Zhao Dang (Vestavia Hills, AL); Venkat R. Chintareddy (Vestavia Hills, AL); V. Satish Kumar (Birmingham, AL); Krishnan Raman (Birmingham, AL)
Assignee:
BioCryst Pharmaceuticals, Inc.
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
Claims (3)
1. A compound, or a pharmaceutically acceptable salt thereof, having the following structure:
2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
3. The compound of claim 1 , wherein the compound is in the form of a hydrochloride salt.
Assignments (2)
SECURITY INTEREST
Recorded Jan 23, 2026
From: BIOCRYST PHARMACEUTICALS, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 074485/0651 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 23, 2021
From: KOTIAN, PRAVIN L.; BABU, YARLAGADDA S.; ZHANG, WEIHE; LU, PENG-CHENG; WU, MINWAN; LV, WEI; NGUYEN, TRUNG XUAN; DANG, ZHAO; CHINTAREDDY, VENKAT R.; KUMAR, V. SATISH; RAMAN, KRISHNAN
To: BIOCRYST PHARMACEUTICALS, INC.
Reel/Frame 057253/0466 →