Miniaturized wearable medication administration device
A device includes a housing having a first end, a second end, a first cylinder, a second cylinder parallel to the first cylinder, and a channel connecting the first and second cylinders near the second end. A piston is positioned within the first cylinder. A cartridge containing a therapeutic agent is positioned within the second cylinder. A needle hub containing a needle is positioned within the second cylinder between the cartridge and the first end. A septum is positioned at the first end. A fluid is positioned within the first cylinder. When the device is activated, the piston travels toward the second end, forcing some of the fluid to travel from the first cylinder into the second cylinder, forcing the cartridge toward the first end, causing the needle to penetrate the cartridge and the septum, and causing at least some of the therapeutic agent to extrude through the needle.
1 . A device, comprising:
a housing having a first end, a second end, a first section extending from the first end to the second end, a second section to the first section, and a channel connecting the first section to the second section proximate to the second end;
a stored energy system configured to deliver pressurized fluid, the fluid including a hydraulic fluid, the stored energy system including:
a piston slidably positioned within the first section adjacent to a volume of fluid contained in the first section; and
a deployment spring disposed in the first section and configured to move the piston toward the second end of the housing such that the volume of fluid contained in the first section is driven through the channel and into the second section;
a penetrable septum configured to separate an interior of the housing from an external environment surrounding the housing;
a cartridge having a first end and a second end, wherein the cartridge contains at least one therapeutic agent, wherein the cartridge has a plunger disposable at the second end of the cartridge and movable within the cartridge toward the first end of the cartridge, wherein the cartridge is slidably positioned within the second section such that the second end of the cartridge faces the second end of the housing;
a cartridge sealing ring positioned directly adjacent to and in contact with the second end of the cartridge, wherein the volume of fluid is configured to drive movement of the cartridge sealing ring toward the first end of the housing to drive the movement of cartridge toward the first end of the housing;
a dual-ended needle positioned between the cartridge and the septum; and
an activation trigger configured to be actuated to release the piston and the deployment spring to drive the volume of fluid from the first section to the second section to drive:
movement of the cartridge and the needle toward the septum such that the needle penetrates the septum and inserts into skin adjacent to the septum;
movement of the cartridge toward the needle such that the needle penetrates the first end of the cartridge; and
movement of the plunger within the cartridge to force at least a portion of the at least one therapeutic agent to extrude through the needle and into the skin.
2 . The device of claim 1 , further comprising a retraction spring positioned within the second section, wherein the retraction spring is configured to retract the needle toward the second end of the housing after the volume of fluid stops driving the movement of the plunger to position the needle entirely within the housing.
3 . The device of claim 2 , wherein the piston includes a sealing element, wherein the first section includes a relief bore positioned proximate to the second end of the housing, wherein the relief bore is configured such that, when the sealing element is positioned between the relief bore and the second end of the housing, the volume of fluid is permitted to flow into a portion of the first section between the sealing element and the first end of the housing, thereby removing pressure from the cartridge and stopping the volume of fluid from driving the movement of the plunger.
4 . The device of claim 3 , wherein a position of the relief bore is configured so as to control an amount of the at least one therapeutic agent to be extruded through the needle.
5 . The device of claim 3 , wherein the deployment spring and the retraction spring are configured such that an elapsed time between an actuation of the activation trigger and a subsequent retraction of the needle is less than 2.0 seconds.
6 . The device of claim 1 , wherein a length of the device is between 10 millimeters and 67.5 millimeters.
7 . The device of claim 1 , wherein a height of the device is between 5 millimeters and 16 millimeters.
8 . The device of claim 1 , further comprising a clip configured to removably attach the device to at least one of a person or an item.
9 . The device of claim 8 , wherein the clip includes at least one of a slide-on clip or a pinch clip.
10 . The device of claim 1 , wherein the housing is configured to reflect infrared radiation.
11 . The device of claim 1 , wherein the housing includes a semi-permeable barrier overlaying the penetrable septum.
12 . The device of claim 11 , wherein the semi-permeable barrier comprises flash-spun high-density polyethylene.
13 . The device of claim 11 , wherein the housing is fluid-tight.
14 . The device of claim 1 , wherein the at least one therapeutic agent is a plurality of therapeutic agents.
15 . The device of claim 1 , further comprising at least one sensor.
16 . The device of claim 1 , wherein the activation trigger is configured to be actuated to release the piston and the deployment spring to drive the volume of fluid from the first section to the second section to drive the movement of the cartridge and the needle toward the septum, followed by the movement of the cartridge toward the needle, and further followed by the movement of the plunger within the cartridge, such that the needle is inserted into the skin and is disposed in the cartridge prior to the at least one therapeutic agent being extruded through the needle.
17 . The device of claim 1 , wherein the activation trigger is disposed on the first end of the housing and the needle is configured to penetrate through the septum on the first end of the housing, the activation trigger configured to be actuated when the first end of the housing is pressed against the skin.
18 . The device of claim 1 , wherein the second section is disposed parallel to the first section.
19 . The device of claim 1 , wherein the activation trigger is disposed on a longitudinal axis of the first section.
20 . The device of claim 1 , wherein a longitudinal axis of the activation trigger is perpendicular with a longitudinal axis of the dual-ended needle.