Compositions and methods for delivering cannabinoids to skin
Provided herein are compositions for delivering one or more cannabinoids to the skin of a subject and methods of using the compositions to deliver the one or more cannabinoids to the skin of a subject. The compositions contain a carrier that facilitates the delivery and permeation of cannabinoids to and through the skin. The carriers of the compositions contain squalane or mixtures of squalane and hemisqualane. The compositions described herein may serve as the base for the preparation of various cosmetics or various pharmaceuticals. The cosmetics or pharmaceuticals may be used to reduce inflammation, control pain, or prevent aging of the skin of a subject.
1. A composition comprising a carrier and one or more cannabinoids, wherein the carrier comprises squalane.
2. The composition of claim 1 , wherein the carrier further comprises hemisqualane.
3. The composition of claim 2 , wherein the squalane and hemisqualane are present in a ratio from about 10 to 1 (squalane to hemisqualane) by weight to about 1 to 10 (squalane to hemisqualane) by weight.
4. The composition of claim 3 , wherein the squalane and hemisqualane are present in a ration of about 1 to 1 by weight.
5. The composition of claim 1 , wherein the one or more cannabinoids comprises from about 0.01% w/w to about 10% w/w of the composition.
6. The composition of claim 5 , wherein the one or more cannabinoids comprises from about 0.3% w/w to about 1% w/w of the composition.
7. The composition of claim 6 , wherein the one or more cannabinoids comprises about 0.7% w/w of the composition.
8. The composition of claim 1 , wherein the squalane comprises from about 10% w/w to about 99.9% w/w of the composition.
9. The composition of claim 1 , wherein the one or more cannabinoids is selected from cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabielsoin (CBE), cannabicitran (CBT), tetrahydrocannabinol (THC), and tetrahydrocannabinolic acid (THCA).
10. The composition of claim 9 , wherein the one or more cannabinoids comprises cannabigerol (CBG).
11. The composition of claim 9 , wherein the one or more cannabinoids comprises cannabidiol (CBD).
12. The composition of claim 1 , wherein the squalane is from about 15% w/w to about 99.9% w/w of the composition.
13. The composition of claim 1 , wherein the squalane is from about 20% w/w to about 99.9% w/w of the composition.
14. The composition of claim 1 , wherein the squalane is from about 25% w/w to about 99.9% w/w of the composition.
15. The composition of claim 1 , wherein the squalane is from about 35% w/w to about 99.9% w/w of the composition.
16. The composition of claim 1 , wherein the squalane is from about 45% w/w to about 99.9% w/w of the composition.
17. The composition of claim 14 , wherein the one or more cannabinoids comprises cannabidiol (CBD) or cannabigerol (CBG).
18. The composition of claim 16 , wherein the one or more cannabinoids comprises cannabidiol (CBD) or cannabigerol (CBG).
19. A cosmetic comprising a carrier and a cannabinoid, wherein the carrier comprises squalane.
20. The cosmetic of claim 19 further comprising one or more excipients selected from the group consisting of natural oils, synthetic oils, emulsifiers, emollients, lipids, humectants, moisturizers, binders, conditioning agents, emulsion stabilizing salts, preservatives, chelating agents, sequestering agents, abrasives, pH adjusters, surfactants, perfumes and colorings.
21. The cosmetic of claim 19 , wherein the carrier further comprises hemisqualane.
22. The cosmetic of claim 21 , wherein the squalane and hemisqualane are present in a ratio of about 10 to 1 (squalane to hemisqualane) by weight to about 1 to 10 (squalane to hemisqualane) by weight.
23. The cosmetic of claim 19 , wherein the cannabinoid is selected from cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabielsoin (CBE), cannabicitran (CBT), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), and combinations thereof.
24. The cosmetic of claim 23 , wherein the cannabinoid comprises cannabigerol (CBG).
25. The cosmetic of claim 23 , wherein the cannabinoid comprises cannabidiol (CBD).
26. The cosmetic of claim 19 , further comprising a cosmetic base that is an oleaginous base, emulsifiable base, emulsion base, or water-soluble base.
27. The cosmetic of claim 19 , wherein the squalane is from about 25% w/w to about 99.9% w/w of the composition.
28. A composition comprising a carrier and cannabigerol (CBG) or cannabidiol CBD, wherein the carrier comprises squalane.