Stress test and treatment of chronic kidney disease
The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.
1. A method for treating a patient at risk for having suffered kidney injury or kidney disease progression comprising:
(a) administering a compound to the patient, wherein the compound is a protoporphyrin or mesoporphyrin;
(b) measuring the response of the patient to the compound, wherein the response comprises increased level of expression of one or more anti-oxidant proteins; and
(c) administering a therapy to the patient if the level of expression of the one or more anti-oxidant proteins is above a predefined level.
2. The method of claim 1 , wherein the anti-oxidant proteins comprise one or more of HO-1, ferritin, p21, or NQO1.
3. The method of claim 1 , wherein the level of expression of the one or more anti-oxidant proteins is measured before step (a), and the level of expression of the one or more anti-oxidant proteins measured in step (b) is compared to the level of expression measured before step (a).
4. The method of claim 1 , wherein the patient is suffering from chronic kidney disease.
5. The method of claim 1 , wherein compound is a metal protoporphyrin.
6. The method of claim 5 , wherein the metal protoporphyrin is tin, cobalt, or zinc protoporphyrin.
7. The method claim 1 , wherein the dose of the compound is 9 mg or greater.
8. The method of claim 1 , wherein the therapy comprises administering a potent antioxidant.
9. The method of claim 1 , wherein the therapy comprises administering tetrahydrocurcumen.