Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-IL-23 blocking antibodies
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-IL-23 antibody. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-IL-23 antibody.
1. A method of treating or reducing the development of inflammatory bowel disease in a mammal, said method comprising administering a suitable amount of a CCR9 inhibitor with an anti-IL-23 or anti-IL-23 receptor blocking antibody,
wherein the CCR9 inhibitor is
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the inflammatory bowel disease is Crohn's disease (CD) or ulcerative colitis (UC).
3. The method of claim 1 , wherein the anti-IL-23 or the anti-IL-23 receptor blocking antibody is risankizumab, guselkumab, ustekinumab, briakinumab, brazikumab, mirikizumab, tildrakizumab, or a biosimilar, biobetter, or bioequivalent thereof.
4. The method of claim 1 , wherein the CCR9 inhibitor and the anti-IL-23 receptor blocking anti-IL-23 receptor blocking antibody are administered in a combination formulation.
5. The method of claim 1 , wherein the CCR9 inhibitor and the anti-IL-23 or the anti-IL-23 receptor blocking antibody are administered sequentially.
6. The method of claim 5 , wherein the CCR9 inhibitor is administered prior to the anti-IL-23 or the anti-IL-23 receptor blocking antibody.
7. The method of claim 5 , wherein the CCR9 inhibitor is administered after administration of the anti-IL-23 or the anti-IL-23 receptor blocking antibody.
8. The method of claim 1 , wherein:
the inflammatory bowel disease is Crohn's disease (CD) or ulcerative colitis (UC); and
the anti-IL-23 or the anti-IL-23 receptor blocking antibody is risankizumab, guselkumab, ustekinumab, briakinumab, brazikumab, mirikizumab, or tildrakizumab, or a biosimilar of any of the foregoing.