Compositions Comprising Nicotine and/or Nicotine Salts and Ultrasonic Aerosolisation of Compositions Comprising Nicotine and/or Nicotine Salts
The present invention relates to compositions comprising nicotine and/or salts of nicotine, in particular compositions comprising nicotine and/or salts of nicotine for ultrasonic aerosolisation.
1 . An e-liquid composition for use with an ultrasonic device, comprising:
a nicotine salt.
2 . The e-liquid composition of claim 1 , wherein the e-liquid composition further comprises one, two, three or four of:
propylene glycol;
vegetable glycerin;
water; and,
flavourings.
3 . The e-liquid composition of claim 2 , wherein:
A. the relative amount of vegetable glycerin in the composition is: from 55 to 80% (w/w), or from 60 to 80% (w/w), or from 65 to 75% (w/w), or 70% (w/w); and/or,
B. the relative amount of propylene glycol in the composition is: from 5 to 30% (w/w), or from 10 to 30% (w/w), or from 15 to 25% (w/w), or 20% (w/w); and/or,
C. the relative amount of water in the composition is: from 5 to 15% (w/w), or from 7 to 12% (w/w), or 10% (w/w); and/or,
D. the amount of nicotine and/or nicotine salt in the composition is: from 0.1 to 80 mg/ml, or from 0.1 to 50 mg/ml, or from 1 to 25 mg/ml, or from 10 to 20 mg/ml, or 17 mg/ml.
4 . The e-liquid composition of claim 2 , wherein the composition comprises, or consists of, (in % (w/w)):
propylene glycol
from 10 to 20
vegetable glycerin
from 65 to 75
water
from 5 to 15
nicotine
from 1 to 5
organic acid
from 0.1 to 5.0
flavourings
balance;
wherein the organic acid comprises, or consists of: benzoic acid, levulinic acid, malic acid, tartaric acid, salicylic acid, citric acid or lactic acid, or any combination of any two, three, four, five, six of seven of these organic acids.
5 . The e-liquid composition of claim 2 , wherein the composition comprises (in % (w/w)):
organic acid from 0.1 to 5.0; or, from 1.0 to 4.0; or, from 0.1 to 2.0.
6 . The e-liquid composition of claim 2 , wherein the composition comprises, or consists of, (in % (w/w)):
propylene glycol
from 11 to 16
vegetable glycerin
from 69 to 71
water
from 9 to 11
nicotine
from 1 to 3
levulinic acid
from 0.1 to 4.0
flavourings
balance.
7 . The e-liquid composition of claim 6 , wherein the composition comprises (in % (w/w)):
propylene glycol from 14 to 16.
8 . The e-liquid composition of claim 1 , wherein the composition comprises (in % (w/w)):
levulinic acid from 1.0 to 4.0; or, from 0.1 to 1.0; or, from 0.1 to 0.5.
9 . The e-liquid composition of claim 6 , wherein the composition comprises (in % (w/w)):
propylene glycol
15.1
vegetable glycerin
70
water
10
nicotine
1.7
levulinic acid
0.2
flavourings
3; or,
propylene glycol
12.87
vegetable glycerin
70
water
10
nicotine
1.7
levulinic acid
2.43
flavourings
3; or,
propylene glycol
14.08
vegetable glycerin
70
water
10
nicotine
1.7
levulinic acid
1.22
flavourings
3; or,
propylene glycol
11.64
vegetable glycerin
70
water
10
nicotine
1.7
levulinic acid
3.66
flavourings
3.
10 . The e-liquid composition of claim 1 , wherein the nicotine salt is selected from the group consisting of:
nicotine benzoate, nicotine lactate, nicotine maleate, nicotine ditartrate, nicotine salicylate, nicotine citrate and nicotine levulinate, or any combination of any two, three, four, five, six or seven of these nicotine salts.
11 . The e-liquid composition of claim 1 , wherein the nicotine salt is nicotine levulinate.
12 . The e-liquid composition of claim 10 , wherein the molar ratio of nicotine to organic acid salt (nicotine:organic acid salt) is: 1:1 or greater; or, 1:2 or greater; or, from 1:1 to 1:4; or, from 1:1 to 1:3.
13 . The use of an e-liquid composition in providing nicotine to a user, the use comprising:
providing an e-liquid composition comprising a nicotine salt and at least one of propylene glycol; vegetable glycerin; water; and, flavourings;
placing the e-liquid composition in an ultrasonic device; and,
aerosolising the e-liquid composition in the ultrasonic device.
14 . The use of claim 13 , wherein the use further comprises:
inhaling the aerosolised composition.
15 . The use of claim 13 , wherein the ultrasonic device is an ultrasonic mist inhaler, comprising:
a liquid reservoir structure comprising a liquid chamber adapted to receive liquid to be atomized,
a sonication chamber in fluid communication with the liquid chamber,
a capillary element arranged between the liquid chamber and the sonication chamber.
16 . The use of claim 15 , wherein the capillary element is a material at least partly in bamboo fibers; optionally,
wherein the capillary element material is 100% bamboo fiber; or, wherein the capillary element material is at least 75% bamboo fiber and, preferably, 25% cotton; and/or,
wherein the capillary element is of a thickness between 0.27 mm and 0.32 mm and, preferably, has a density between 38 g/m 2 and 48 g/m 2 .
17 . The use of claim 15 , wherein the capillary element has a flat shape.
18 . The use of claim 15 , wherein the capillary element comprises a central portion and a peripheral portion; optionally,
wherein the peripheral portion has an L-shape cross section extending down to the liquid chamber; and/or
wherein the central portion has a U-shape cross section extending down to the sonication chamber.
19 . A method of delivering a nicotine salt to a user, the method comprising:
providing an e-liquid composition comprising a nicotine salt and at least one of propylene glycol; vegetable glycerin; water; and, flavourings;
placing the e-liquid composition in an ultrasonic device; and,
aerosolising the e-liquid composition in the ultrasonic device.
20 . The method of claim 19 , wherein the method further comprises:
inhaling the aerosolised composition.