Combined fungal composition for modulating inflammatory response

1. A pharmaceutical composition comprising:

200-1,800 mg of an aqueous or solid fraction of Trametes versicolor mycelium, a fermented substrate thereof, or a combination thereof; and

200-1,800 mg of an aqueous or solid fraction of Fomitopsis officinalis mycelium, a fermented substrate thereof, or a combination thereof.

2. The composition of claim 1 , wherein the aqueous or solid fraction comprises beta-glucans.

3. The composition of claim 1 , wherein the composition comprises a buffering agent.

4. The composition of claim 3 , wherein the buffering agent comprises phosphate buffered saline.

5. A pharmaceutical composition for treating, prophylaxis of, or ameliorating symptoms of one or more adverse reactions triggered by an infectious disease or condition that increases an anti-inflammatory response in a subject, the composition comprising:

200-1,800 mg of an aqueous, hydroethanolic, ethanolic, or solid fraction of Trametes versicolor mycelium, a fermented substrate thereof, or a combination thereof;

200-1,800 mg of an aqueous or solid fraction of Fomitopsis officinalis mycelium, a fermented substrate thereof, or a combination thereof;

one or more buffering agents;

ethanol; and

water.

6. The composition of claim 5 , wherein the aqueous or solid fraction comprises beta-glucans.

7. The composition of claim 5 , wherein the buffering agent comprises phosphate buffered saline.

8. The composition of claim 5 , wherein the infectious disease comprises a bacterial infection.

9. The composition of claim 8 , wherein the bacterial infection comprises one or more of Streptococcus pneumoniae, Mycobacterium tuberculosis, Bordetella pertussis, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, Stenotrophomonas maltophila, Staphylococcus aureus, Streptococcus pyogenes, Neisseria meningitidis, Klebsiella pneumoniae , or Non-tuberculosis Mycobacterium.

10. The composition of claim 5 , wherein the infectious disease comprises a viral infection.

11. The composition of claim 10 , wherein the viral infection comprises one or more of Paramyxoviridae (respiratory syncytial virus (RSV), parainfluenza virus (PIV), metapneumovirus (MPV), enteroviruses), Picornaviridae (Rhinovirus, RV), Coronaviridae (CoV), Adenoviridae (Adenovirus), Parvoviridae (HBoV), Orthomyxoviridae (influenza A, B, C, D, Isavirus, Thogotovirus, Quaranjavirus), or Herpesviridae (human herpes viruses, Varicella zoster virus, Epstein-Barr virus, cytomegalovirus).

12. The composition of claim 11 , wherein the CoV comprises one or more of Severe Acute Respiratory Syndrome (SARS-CoV), Middle East Respiratory Syndrome (MERS-CoV), COVID-19 (2019-nCoV, SARS-CoV-2), 229E, NL63, OC43, or HKU1.