Stem cells for wound healing
View Patent ↗The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.
1. A method to promote cutaneous burn healing in a subject by administering cells (I) in an effective amount and for a time sufficient to promote the cutaneous burn healing, wherein the cells (I) are not delivered from a functionalized substrate, wherein the cells (I) are non-embryonic non-germ cells that express CD90 and oct4 or telomerase, are not transformed, are not tumorigenic, and have a normal karyotype.
2. The method of claim 1 , wherein the cells (I) express telomerase.
3. The method of either of claim 1 or 2 , wherein the cells (I) can differentiate into at least one cell type of at least two of the endodermal, ectodermal, and mesodermal embryonic lineages.
4. The method of claim 3 , wherein the cells (I) can differentiate into at least one cell type of each of the endodermal, ectodermal, and mesodermal embryonic lineages.
5. The method of claim 1 , wherein the burn is of the skin and underlying tissues.
6. The method of either of claim 1 or 2 , wherein the cells (I) are not genetically manipulated.
7. The method of either of claim 1 or 2 , wherein the cells (I) are derived from bone marrow.
8. The method of either of claim 1 or 2 , wherein the cells (I) are derived from a human.
9. The method of either of claim 1 or 2 , wherein the subject is human.
10. The method of either of claim 1 or 2 , wherein the cells (I) are administered to the burn topically.
11. The method of either of claim 1 or 2 , wherein the cells (I) are delivered subcutaneously.
12. The method of either of claim 1 or 2 , wherein the cells (I) are administered to the burn by injection.
13. The method of either of claim 1 or 2 , wherein the cells (I) are administered in liquid cell suspension.
14. The method of either of claim 1 or 2 , wherein the cells (I) are administered to the burn using a reservoir.
15. The method of either of claim 1 or 2 , wherein the cells (I) are allogeneic.