Method and composition for enhancing the quality and benefits of sleep
Compounds, compositions and methods of making and using for enhancing the quality and benefit of sleep and/or wakefulness in a subject in need thereof.
1. A composition comprising magnesium di-L-theanate:
wherein the magnesium di-L-theanate exhibits an optical rotation of 3-4°.
2. A method of improving sleep in a subject in need thereof, the method comprising the step of administering an effective amount of magnesium di-L-theanate, wherein the effective amount is about 20 mg/kg body weight, wherein the effective amount is sufficient to decrease sleep latency and/or increase length of sleep, wherein said magnesium di-L-theanate is a solid having a molecular structure of
an optical rotation of 3-4°, and contains 5.5-6.0% by weight magnesium and 94.0-94.5% by weight L-theanate.
3. The method of claim 2 , wherein the magnesium di-L-theanate is formulated for administration to a mammal.
4. The method of claim 3 , wherein the step for administration is administration by mouth.
5. A method of preparation for a magnesium di-L-theanate compound, comprising the steps of:
(a) Dissolving 2 mole equivalents of L-theanine and 1 mole equivalent of magnesium ethoxide in an aqueous alcohol solution, wherein the alcohol in said aqueous alcohol solution is ethanol or methanol;
(b) Allowing said solution to stir at ambient or elevated temperature until a clear solution is obtained;
(c) Removing volatile solvents from said clear solution by evaporation to provide a solid;
(d) Dispersing the solid in an immiscible solvent and removing said solvent by filtration to provide a solid filtrand of purified magnesium di-L-theanate;
(e) Drying said solid filtrand to remove residual solvents and provide purified magnesium di-L-theanate.