CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES
Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
1 . A method of inhibiting pain/inflammation and spasm in the urinary tract, comprising:
delivering to the urinary tract a composition including a combination of ketoprofen and a calcium channel antagonist in a carrier, each of the ketoprofen and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
2 . The method of claim 1 , wherein the composition is delivered periprocedurally to the urinary tract during a urological diagnostic, interventional, surgical and other medical procedure.
3 . The method of claim 2 , wherein the composition is periprocedurally delivered during a cystoscopic procedure.
4 . The method of claim 2 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure.
5 . The method of claim 2 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone.
6 . The method of claim 2 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue.
7 . The method of claim 5 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
8 . The method of claim 2 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate.
9 . The method of claim 1 , wherein the calcium channel antagonist in the composition comprises nifedipine.
10 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a diagnostic, interventional, surgical or other medical urological procedure, comprising:
periprocedurally delivering to the urinary tract during a urological procedure a composition including a combination of ketoprofen and nifedipine in a carrier, each of the ketoprofen and the nifedipine included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
11 . The method of claim 10 , wherein the composition is during a cystoscopic procedure.
12 . The method of claim 10 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure.
13 . The method of claim 10 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone.
14 . The method of claim 10 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue.
15 . The method of claim 10 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
16 . The method of claim 10 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate.
17 . The method of claim 10 , wherein the composition is periprocedurally delivered transrectally or transperitoneally to the prostate.
18 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
19 . The method of claim 18 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.