System and method of measuring venous oxygen saturation using intelligent pulse averaging with integrated EKG and PPG sensors

1. A system for determining venous oxygen saturation, comprising:

(a) a device positionable against skin of a person;

(b) at least one PPG sensor mounted on the device for measuring a PPG signal of the person at multiple wavelengths of light;

(c) a plurality of electrodes for measuring an EKG signal of the person;

(d) a computer logic system for receiving and analyzing the PPG signal and the EKG signal,

wherein the computer logic is configured to:

identify cardiac cycles in the EKG signal;

segment the PPG signal into a series of PPG signal segments based upon features in the identified cardiac cycles,

sort the PPG signal segments into a plurality of bins based upon a similarity in durations of prior R-to-R cardiac cycles and a similarity in durations of current R-to-R cardiac cycles,

generate a composite signal for each of the plurality of bins,

generate a composite Signal Prime Over Signal (SPOS) for each of the composite signals by calculating a derivative of the composite signal and normalizing the derivative of the composite signal by the composite signal itself,

measure venous oxygen saturation of the person by:

(a) calculating arterial oxygen saturation by comparing the composite SPOS signals measured at different wavelengths of light,

(b) sub-sampling composite signals at two consecutive signal maxima measured at different wavelengths of light, and

(c) comparing the sub-sampled composite SPOS signals measured at different wavelengths of light to the calculated arterial oxygen saturation to determine venous oxygen saturation, and

output to a display device an indication of the determined venous oxygen saturation to enable noninvasive monitoring of cardiac conditions.

2. The system of claim 1 , wherein to measure venous oxygen saturation of the person, the computer logic system is configured to select preferred bins from which the composite signals are used when determining the venous oxygen saturation.

3. The system of claim 2 , wherein the preferred bins correspond to the bins having the largest number of PPG signal segments therein.

4. The system of claim 3 , wherein the preferred bins correspond to the bins having the largest difference between current and prior R-to-R values.

5. The system of claim 1 , wherein to generate the composite signal for each of the plurality of bins, the computer logic system is configured to sum or average the PPG signal segments in the bin.

6. The system of claim 1 , wherein to generate the composite signal for each of the plurality of bins, the computer logic system is configured to remove aberrant PPG signal segments from the calculation of the composite signal.

7. The system of claim 6 , wherein to remove aberrant PPG signal segments from the calculation of the composite signal, the computer logic system is configured to iteratively recalculate the composite signal, by:

comparing a SPOS of each of the PPG signal segments used to calculate a composite signal against the SPOS of the calculated composite signal,

removing outlier PPG signal segments,

re-calculating the composite signal with the outlier PPG signal segments removed, and repeating the iteration until there are no more outlier PPG signal segments.

8. The system of claim 1 , wherein the device is a hand-held device with the at least one PPG sensor mounted thereon and a plurality of electrode wires extending therefrom.

9. The system of claim 8 , wherein the device is a hand-held device with the at least one PPG sensor mounted thereon and at least one of the plurality of electrodes mounted thereon.

10. The system of claim 8 , wherein an optical waveguide is interposed between the at least one PPG sensor on the device and the skin of the person.

11. The system of claim 1 , wherein the device is positioned within a strap or band disposed around a chest or limb of the person such that the at least one PPG sensor and the plurality of electrodes are disposed within the strap or band disposed around the chest or limb of the person.

12. The system of claim 1 , wherein the device is a patch with the at least one PPG sensor and at least one of the plurality of electrodes positioned therein.

13. The system of claim 1 , wherein the computer logic system is positioned within the device such that the composite signals are generated within the device, and wherein the device comprises:

a data transmission system for transmitting one or both of:

the composite signals to a remote computer system for analysis, or measured PPG and EKG signals to a remote computer system for analysis.

14. A system for determining venous oxygen saturation, comprising:

(a) a device positionable against skin of a person;

(b) at least one PPG sensor mounted on the device for measuring a PPG signal of the person at multiple wavelengths of light;

(c) a plurality of electrodes for measuring an EKG signal of the person;

(d) a computer logic system for receiving and analyzing the PPG signal and the EKG signal,

wherein the computer logic system is configured to:

identify cardiac cycles in the EKG signal;

segment the PPG signal into a series of PPG signal segments based upon features in the identified cardiac cycles,

sort the PPG signal segments into a plurality of bins based upon a similarity in durations of prior R-to-R cardiac cycles and a similarity in durations of current R-to-R cardiac cycles,

generate a composite signal for each of the plurality of bins by summing or averaging the PPG signal segments in the bin, and

generate composite Signal Prime Over Signal (SPOS) for each of the composite signals by calculating a derivative of the composite signal and normalizing the derivative of the composite signal by the composite signal itself, and

measure venous oxygen saturation of the person by:

(a) calculating arterial oxygen saturation by comparing the composite SPOS signals measured at different wavelengths of light,

(b) sub-sampling composite signals at two consecutive signal maxima measured at different wavelengths of light, and

(c) comparing the sub-sampled composite signals measured at different wavelengths of light to the calculated arterial oxygen saturation to determine venous oxygen saturation.

15. A system for determining venous oxygen saturation, comprising:

(a) a device positionable against skin of a person;

(b) at least one PPG sensor mounted on the device for measuring a PPG signal of the person at multiple wavelengths of light;

(c) a plurality of electrodes for measuring an EKG signal of the person;

(d) a computer logic system for receiving and analyzing the PPG signal and the EKG signal,

wherein the computer logic system is configured to:

identify cardiac cycles in the EKG signal;

segment the PPG signal into a series of PPG signal segments based upon features in the identified cardiac cycles,

sort the PPG signal segments into a plurality of bins based upon a similarity in durations of prior R-to-R cardiac cycles and a similarity in durations of current R-to-R cardiac cycles,

generate a composite signal for each of the plurality of bins comprising a system for removing aberrant PPG signal segments from the calculation of the composite signal by iteratively re-calculating the composite signal, by:

comparing a SPOS of each of the PPG signal segments used to calculate a composite signal against the SPOS of the calculated composite signal,

removing outlier PPG signal segments,

re-calculating the composite signal with the outlier PPG signal segments removed, and

repeating the iteration until there are no more outlier PPG signal segments, and measure a person's venous oxygen saturation by:

(a) calculating arterial oxygen saturation by comparing composite signals measured at different wavelengths of light,

(b) sub-sampling composite signals at two consecutive signal maxima measured at different wavelengths of light, and

(c) comparing the sub-sampled composite signals measured at different wavelengths of light to the calculated arterial oxygen saturation to determine venous oxygen saturation.