Flow cell for use in a fluid management and/or processing system
View Patent ↗A flow cell for use in a fluid management and/or processing system is disclosed, said flow cell comprising a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet. Said body further comprises a receptacle comprising a chamber forming a part of the fluid flow channel, said chamber comprising a first opening for connecting a functional element to the flow cell such that the functional element is in contact with or exposed to a fluid flow passing through the fluid flow channel. A first tubular connector is arranged adjacent to the inlet. A second tubular connector is arranged adjacent to the outlet. The flow cell further comprises a functional element and a fluid flow path extending from the first tubular connector through the inlet, the body, the receptacle, and the outlet, to the second tubular connector.
1. A tubing arrangement for use in a fluid management and/or processing system, the tubing arrangement comprising first, second, third, and fourth flow cells, each flow cell comprising a functional element and
a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet, said body further comprising a receptacle comprising a chamber forming a part of the fluid flow channel, said chamber comprising a first opening for connecting the functional element, wherein the functional element comprises a first conductivity sensor, a pH sensor, a second conductivity sensor, or a pressure sensor, to the flow cell, such that the functional element is in contact with or exposed to a fluid flow passing through the fluid flow channel;
a first tubular connector arranged adjacent to the inlet;
a second tubular connector arranged adjacent to the outlet;
a fluid flow path extending from the first tubular connector through the inlet, the body and the receptacle to the outlet to the second tubular connector, wherein the first flow cell comprises the first conductivity sensor, the second flow cell comprises the pH sensor, the third flow cell comprises the second conductivity sensor, and the fourth flow cell comprises the pressure sensor, wherein the second flow cell comprising the pH sensor is arranged between the first flow cell comprising the first conductivity sensor and the third flow cell comprising the second conductivity sensor, wherein the fourth flow cell is arranged between, and in fluid communication with, the first flow cell and the second flow cell, and
an integrity test line arranged between, and in fluid communication with, the first flow cell and the second flow cell, wherein the fourth flow cell is also in fluid communication with the integrity test line.
2. The tubing arrangement according to claim 1 , comprising additional flow cells comprising functional elements selected from a static mixer, a conductivity sensor, an additional pH sensor, an additional pressure sensor, an electrical grounding element, a redox sensing element, a temperature sensor, a capacitive sensor, an optical sensor, a flow sensor, and an element for taking liquid samples.
3. The tubing arrangement according to claim 1 , wherein said fluid flow path in each of the first, second, third, and fourth flow cells has a predetermined, essentially consistent cross-sectional area at least within and along the first and second tubular connectors.
4. The tubing arrangement according to claim 3 , wherein the volume of the chamber of the body of each of the first, second, third, and fourth flow cells is designed to provide a cross-sectional area of the fluid flow path equal to or larger than the cross-sectional area of the fluid flow path within and along the first and second tubular connectors.
5. The tubing arrangement according to claim 4 , wherein a probe end of the functional element comprising the first conductivity sensor, the pH sensor, the second conductivity sensor, or the pressure sensor extending into the chamber is positioned such that the probe end keeps a distance to wall parts of the chamber of about 12 mm or more.
6. The tubing arrangement according to claim 4 , wherein the volume of the chamber of the body of each of the first, second, third, and fourth flow cells is designed to provide a cross-sectional area of the fluid flow path equal to or larger than the cross-sectional area of the fluid flow path within and along the first and second tubular connectors, once the functional element is mounted in the opening.
7. The tubing arrangement according to claim 6 , wherein once the functional element is mounted in the opening, the functional element extends with a probe end into the chamber.
8. The tubing arrangement according to claim 4 , wherein a probe end of the functional element comprising the first conductivity sensor, the pH sensor, the second conductivity sensor or the pressure sensor extending into the chamber is positioned such that the probe end keeps a distance to wall parts of the chamber of about 15 mm or more.
9. The tubing arrangement according claim 1 , wherein said tubular connectors are directly attached to the body of each of the first, second, third, and fourth flow cells.
10. The tubing arrangement according to claim 9 , wherein the tubular connectors of each of the first, second, third, and fourth flow cells are formed integrally with the body.
11. The tubing arrangement according to claim 1 , wherein said body and/or said tubular connectors of each of the first, second, third, and fourth flow cells are made of metal, or a plastics material.
12. The tubing arrangement according to claim 1 , wherein the fluid flow channel of each of the first, second, third, and fourth flow cells has a straight configuration; or wherein the fluid flow channel is of an arcuate or curved configuration, or an angled configuration.
13. The tubing arrangement according to claim 12 , wherein the fluid flow channel of each of the first, second, third, and fourth flow cells is of a 90 degree angled configuration, or a T-shaped configuration.
14. The tubing arrangement according to claim 1 , wherein the chamber of the receptacle of each of the first, second, third, and fourth flow cells has a second opening opposite to the first opening.
15. The tubing arrangement according to claim 14 , the second opening provides one of the inlet and the outlet.
16. The tubing arrangement according to claim 1 , wherein the chamber of the receptacle of each of the first, second, third, and fourth flow cells has an essentially hollow cylindrical shape.
17. The tubing arrangement according to claim 1 , wherein the first opening of the chamber of each of the first, second, third, and fourth flow cells comprises a circular projection extending away from said body to receive said functional element.
18. The tubing arrangement according to claim 1 , wherein said first opening of the chamber of each of the first, second, third, and fourth more flow cells accommodates an adapter for positioning one end of the functional element in a predefined position.
19. The tubing arrangement according to claim 1 , wherein each of the first, second, third, and fourth flow cells is designed for single use and/or to be sterilized.
20. The tubing arrangement according to claim 1 , wherein the cross-sectional area of the fluid flow path of each of the first, second, third, and fourth flow cells along the flow channel corresponds essentially to the cross-sectional area in the first and second tubular connectors.
21. The tubing arrangement according to claim 1 , including an inlet port and an inlet line incorporating one of the first, second, and third third, and fourth flow cells.
22. The tubing arrangement according to claim 21 , including a pump connected to the inlet line, arranged to provide flow from the inlet port to the tubing arrangement.
23. A fluid management and/or processing system comprising a tubing arrangement comprising first, second, third, and fourth flow cells, each flow cell comprising a functional element and
a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet, said body further comprising a receptacle comprising a chamber forming a part of the fluid flow channel, said chamber comprising a first opening for connecting the functional element, wherein the functional element comprises a first conductivity sensor, a pH sensor, a second conductivity sensor, or a pressure sensor, to the flow cell, such that the functional element is in contact with or exposed to a fluid flow passing through the fluid flow channel;
a first tubular connector arranged adjacent to the inlet;
a second tubular connector arranged adjacent to the outlet;
a fluid flow path extending from the first tubular connector through the inlet, the body and the receptacle to the outlet to the second tubular connector, wherein the first flow cell comprises the first conductivity sensor, the second flow cell comprises the pH sensor, the third flow cell comprises the second conductivity sensor, and the fourth flow cell comprises the pressure sensor, and wherein the second flow cell comprising the pH sensor is arranged between the first flow cell comprising the first conductivity sensor and the third flow cell comprising the second conductivity sensor, wherein the fourth flow cell is arranged between, and in fluid communication with, the first flow cell and the second flow cell, and
an integrity test line arranged between, and in fluid communication with, the first flow cell and the second flow cell, wherein the fourth flow cell is also in fluid communication with the integrity test line.
24. The fluid management and/or processing system of claim 23 , wherein the system forms a part of a bioprocessing system.
25. The fluid management and/or processing system of claim 23 , wherein the tubing arrangement is arranged in a bulk fill manifold.
26. The fluid management and/or processing system of claim 23 , wherein the first and second flow cells each have 90 degree angled configuration, or a T-shaped configuration, and the third and fourth flow cells each have a straight configuration.