IP Library › Granted Patent US 12,310,730
Granted Patent B2
US 12,310,730 · App. 17/230,804 · Granted May 27, 2025

Diagnostic system

Inventors: Sayeed Andeshmand (Dublin, CA); Thomas H. Cauley, III (Redwood City, CA); John Dixon (Moss Beach, CA); David Glade (San Ramon, CA); Hédia Maamar (El Dorado Hills, CA); Michael John McAdams (Los Gatos, CA); Dzam-Si Jesse Ng (Fremont, CA); David Alexander Rolfe (San Francisco, CA)
Assignee: Talis Biomedical Corporation
A61B5/150961A61B5/150755B01L3/502761C12Q1/689A61B5/150221B01L2200/16B01L2300/047B01L2300/0681B01L2300/0809C12Q1/6844C12Q1/6888
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Quick Facts
Patent No.
US 12,310,730
App. No.
17/230,804
Granted
May 27, 2025
Kind
B2
Abstract

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Claims (43)

1. An apparatus, comprising:

an enclosure having an interior portion;

an opening in the enclosure to provide access to the interior portion of the enclosure;

a fixed support bracket within the interior portion of the enclosure;

a moving support bracket within the interior portion of the enclosure and moveable relative to the fixed support bracket and the opening;

a first imaging system within the interior portion of the enclosure adjacent to the opening, the first imaging system configured to collect images from a first imaging area within the interior portion of the enclosure;

a second imaging system within the interior portion of the enclosure configured to collect images from a second imaging area within the interior portion of the enclosure wherein the second imaging area is in non-overlapping relation to the first imaging area;

a rotary connector and a pneumatic connector within the interior portion of the enclosure between the first imaging system and the second imaging system and;

a drive system on the fixed support bracket configured to position the moving support bracket relative to the fixed support bracket.

2. The apparatus according to claim 1 further comprising: a magnetic mixer within the interior portion of the enclosure between the first imaging system and the second imaging system.

3. The apparatus according to claim 1 further comprising a plurality of perforations formed in the fixed support bracket and arranged in a circular pattern adjacent to a magnetic mixing assembly within the enclosure.

4. The apparatus according to claim 1 wherein the first imaging system and the second imaging system are mounted on the fixed support bracket.

5. The apparatus of claim 1 wherein the rotary connector and the pneumatic connector are mounted on the moving support bracket.

6. The apparatus of claim 1 wherein the opening in the enclosure is in a vertical orientation accessing a space between the fixed support bracket and the moving support bracket.

7. The apparatus of claim 1 further comprising a cartridge heater on the fixed support bracket and a series of cutouts machined into the fixed support bracket arranged to form a cartridge heater zone within the enclosure.

8. The apparatus of claim 3 wherein the magnetic mixing assembly further comprises a vertically oriented driven magnet system and a vertically oriented drive magnetic system.

9. The apparatus of claim 1 wherein the opening is a slot, wherein the slot is aligned to access an upper rail within the enclosure aligned to an upper portion of the slot and a lower rail within the enclosure aligned to a lower portion of the slot.

10. The apparatus of claim 9 further comprising a loading and ejection mechanism within the enclosure in sliding relation to the lower rail.

11. The apparatus of claim 10 wherein the loading and ejection mechanism moves between a loading position adjacent to the first imaging system and a loaded position adjacent to the second imaging system and when in the loaded position the loading and ejection mechanism is engaged with a load position sensor.

12. The apparatus of claim 11 wherein the load position sensor provides an electronic indication when the loading and ejection mechanism has translated into the loaded position.

13. The apparatus of claim 3 wherein the fixed support bracket further comprises a heat staker assembly having a staker blade positioned to move relative to a depth stop frame.

14. An apparatus, comprising:

an enclosure;

a fixed support bracket within the enclosure;

a first imaging system mounted on the fixed support bracket within the enclosure adjacent to an opening, the first imaging system configured to collect images from a first imaging area within the enclosure;

a second imaging system mounted on the fixed support bracket within the enclosure configured to collect images from a second imaging area within the enclosure wherein the second imaging area is in non-overlapping relation to the first imaging area;

a moving support bracket within the enclosure and moveable relative to the fixed support bracket, the first imaging system and the second imaging system wherein the moving support bracket is positioned between the first imaging system and the second imaging system;

a drive system on the fixed support bracket configured to position the moving support bracket relative to the fixed support bracket; and

the opening is positioned in the enclosure to provide access to an interior portion of the enclosure between the fixed support bracket and the moving support bracket.

15. The apparatus of claim 14 wherein a rotary connector and a pneumatic connector are connected to and move with the moving support bracket.

16. The apparatus of claim 14 wherein the opening is a slot, wherein the slot is aligned to access an upper rail within the enclosure aligned to an upper portion of the slot and a lower rail within the enclosure aligned to a lower portion of the slot.

17. The apparatus of claim 16 wherein the upper rail and the lower rail extend between the fixed support bracket and the moving support bracket.

18. The apparatus of claim 16 wherein movement of the moving support bracket towards the fixed support bracket is also movement towards the upper rail and the lower rail.

19. The apparatus of claim 16 further comprising a loading and ejection mechanism within the enclosure in sliding relation to the lower rail.

20. The apparatus of claim 19 wherein the loading and ejection mechanism moves between a loading position and a loaded position wherein when in the loading position the loading and ejection mechanism is positioned in a forward most position towards the slot and when in the loaded position the loading and ejection mechanism is engaged with a load position sensor.

21. The apparatus of claim 20 , wherein the loading position is closer to the first imaging system than the second imaging system and the loaded position is closer to the second imaging system than the first imaging system.

22. The apparatus of claim 20 wherein the load position sensor provides an electronic indication when the loading and ejection mechanism has translated into the loaded position.

23. The apparatus of claim 14 further comprising a first heater and a second heater mounted on the fixed support bracket.

24. The apparatus of claim 23 wherein the first heater is positioned to heat a portion of the fixed support bracket between the first imaging area and the second imaging area.

25. The apparatus of claim 23 wherein the second heater is positioned to heat a portion of the fixed support bracket only within the second imaging area.

26. The apparatus of claim 14 further comprising a channel in the fixed support bracket and a heat stake assembly positioned to move a heating element through the channel.

27. The apparatus of claim 26 wherein the channel is positioned on the fixed support bracket to allow the heating element to interact within the enclosure between the first imaging area and the second imaging area.

28. The apparatus of claim 26 wherein the channel is positioned within the fixed support bracket such that the heating element may perform a heat staking operation directly adjacent to but outside of the second imaging area.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE STATE/COUNTRY ON THE COVER SHEET PREVIOUSLY RECORDED AT REEL: 66986 FRAME: 149. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Apr 11, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 067097/0916 →
CHANGE OF ADDRESS FROM 3400 BRIDGE PARKWAY, REDWOOD CITY TO 1100 ISLAND DRIVE, SUITE 101, REDWOOD CITY. Recorded Apr 2, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066986/0144 →
CHANGE OF ADDRESS FROM 1100 ISLAND DRIVE, SUITE 101, REDWOOD CITY TO 1375 WEST FULTON MARKET, SUITE 700, CHICAGO. Recorded Apr 2, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066986/0149 →
CHANGE OF ADDRESS FROM 230 CONSTITUTION DRIVE, MENLO PARK TO 3400 BRIDGE PARKWAY, REDWOOD CITY. Recorded Mar 27, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066926/0028 →
CORRECTIVE ASSIGNMENT TO CORRECT THE 4TH INVENTOR EXECITION DATE PREVIOUSLY RECORDED AT REEL: 57277 FRAME: 481. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 7, 2021
From: ANDESHMAND, SAYEED; CAULEY III, THOMAS H.; DIXON, JOHN; GLADE, DAVID; MAAMAR, HÉDIA; MCADAMS, MICHAEL JOHN; NG, DZAM-SI JESSE; ROLFE, DAVID ALEXANDER
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 057886/0318 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 24, 2021
From: ANDESHMAND, SAYEED; CAULEY III, THOMAS H.; DIXON, JOHN; GLADE, DAVID; MAAMAR, HÉDIA; MCADAMS, MICHAEL JOHN; NG, DZAM-SI JESSE; ROLFE, DAVID ALEXANDER
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 057277/0481 →
Continuity (3)
Continuation 16655028 · Oct 16, 2019
Provisional Application 62887469 · Aug 15, 2019
Related Publication 20210369160A1 · Dec 2, 2021
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