Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof
The present invention relates to the synthesis of intermediate compounds which can be used in the synthesis of mint lactone and related compounds, including 3,6-dimethylhexahydrobenzofuran-2-ones, isomers, and other derivatives.
1. A method of producing (R)-1-(4-methylcyclohex-1-en-1-yl)ethanone, having the general formula (XIX):
Comprising the steps of:
(a) providing a compound having the general formula (VI):
and
(b) dehydrating said compound, to produce the compound of Formula (XIX).
2. The method of claim 1 , wherein said dehydration is catalyzed by an acid.
3. The method of claim 2 , wherein said acid is a cationic resin.
4. The method of claim 2 , wherein said dehydration is performed continuously.
5. The method of claim 2 , wherein said dehydration is performed at an elevated temperature.
6. The method of claim 5 , wherein said temperature is between 80° C. and 140° C.
7. The method of claim 3 , wherein said acid is an Amberlyst-type cationic resin.
8. The method of claim 2 , wherein said dehydration is carried out in toluene solvent.
9. The method of claim 6 , wherein said temperature is between 110° C. and 130° C.