IP Library › Granted Patent US 12,209,285
Granted Patent B2
US 12,209,285 · App. 17/232,795 · Granted Jan 28, 2025

Methods for treatment of oncological disorders using an epimetabolic shifter (coenzyme Q10)

Inventors: Niven Rajin Narain (Cambridge, MA); John Patrick McCook (Frisco, TX)
Assignee: BPGbio, Inc.
C12Q1/6886A61K31/00A61K31/122C12Q1/6883G01N33/5735G01N33/57484C12Q2600/106C12Q2600/112C12Q2600/136C12Q2600/158C12Q2600/16G01N2570/00G01N2800/042G01N2800/52
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Quick Facts
Patent No.
US 12,209,285
App. No.
17/232,795
Granted
Jan 28, 2025
Kind
B2
Abstract

Methods and formulations for treating oncological disorders in humans using Coenzyme Q10 are described.

Claims (18)

1. A method for treating or preventing an oncological disorder in a human, comprising administering Coenzyme Q10 (CoQ10) to the human such that treatment or prevention occurs, wherein the CoQ10 is in its oxidized form and has a purity between 95% and 100%, and wherein administration of the CoQ10 to the human results in an increase of CoQ10 in the oxidized form in the human.

2. The method of claim 1 , wherein CoQ10 induces apoptosis or a cell death mechanism in a cancerous cell of the oncological disorder.

3. The method of claim 1 , wherein the oncological disorder is Squamous cell Carcinoma.

4. The method of claim 1 , wherein the oncological disorder is Basal Cell Carcinoma.

5. The method of claim 1 , wherein the oncological disorder is melanoma.

6. The method of claim 1 , wherein the oncological disorder is selected from the group consisting of pancreatic carcinoma, hepatocellular carcinoma, Ewing's sarcoma, breast cancer, metastatic melanoma, brain cancer, astrocytoma, glioblastoma, neuroendocrine cancer, colon cancer, lung cancer, osteosarcoma, prostate cancer, ovarian cancer and non-Hodgkin's Lymphoma.

7. A method for treating or preventing an oncological disorder in a human, comprising: administering Coenzyme Q10 to the human such that treatment of the oncological disorder occurs, wherein the Coenzyme Q10 is administered such that it is maintained in its oxidized form during treatment.

8. The method of claim 1 , wherein the oncological disorder is selected from the group consisting: a leukemia, a lymphoma, a melanoma, a carcinoma and a sarcoma.

9. The method of claim 1 , further comprising a treatment regimen selected from the group consisting of surgery, radiation, hormone therapy, antibody therapy, therapy with growth factors, cytokines, and chemotherapy.

10. The method of claim 1 , wherein the Coenzyme Q10 is administered by intravenous administration.

11. The method of claim 1 , wherein the Coenzyme Q10 is administered by topical administration.

12. The method of claim 1 , wherein the Coenzyme Q10 is administered with an additional therapeutic agent.

13. The method of claim 12 , wherein the Coenzyme Q10 is administered concurrently with the additional therapeutic agent.

14. The method of claim 12 , wherein the Coenzyme Q10 is administered prior to administration of the additional therapeutic agent.

15. The method of claim 12 , wherein the Coenzyme Q10 is administered subsequent to administration of the additional therapeutic agent.

16. The method of claim 12 , wherein the additional therapeutic agent is a chemotherapeutic agent.

17. The method of claim 16 , wherein the chemotherapeutic agent is selected from the group consisting of amifostine (ethyol), cisplatin, dacarbazine (DTIC), dactinomycin, mechlorethamine (nitrogen mustard), streptozocin, cyclophosphamide, carrnustine (BCNU), lomustine (CCNU), doxorubicin (adriamycin), doxorubicin lipo (doxil), gemcitabine (gemzar), daunorubicin, daunorubicin lipo (daunoxome), procarbazine, mitomycin, cytarabine, etoposide, methotrexate, 5-fluorouracil (5-FU), vinblastine, vincristine, bleomycin, paclitaxel (taxol), docetaxel (taxotere), aldesleukin, asparaginase, busulfan, carboplatin, cladribine, camptothecin, CPT-I1, 1O-hydroxy-7-ethyl-camptothecin (SN38), dacarbazine, S-I capecitabine, ftorafur, 5′deoxyflurouridine, UFT, eniluracil, deoxycytidine, 5-azacytosine, 5-azadeoxycytosine, allopurinol, 2-chloro adenosine, trimetrexate, aminopterin, methylene-10-deazaaminopterin (MDAM), oxaplatin, picoplatin, tetraplatin, satraplatin, platinum-DACH, ormaplatin, CI-973, JM-216, and analogs thereof, epirubicin, etoposide phosphate, 9-aminocamptothecin, 10, 11-methylenedioxycamptothecin, karenitecin, 9-nitrocamptothecin, TAS 103, vindesine, L-phenylalanine mustard, ifosphamidemefosphamide, perfosfamide, trophosphamide carmustine, semustine, epothilones A-E, tomudex, 6-mercaptopurine, 6-thioguanine, amsacrine, etoposide phosphate, karenitecin, acyclovir, valacyclovir, ganciclovir, amantadine, rimantadine, lamivudine, zidovudine, bevacizumab, trastuzumab, rituximab, 5-Fluorouracil, Capecitabine, Pentostatin, Trimetrexate, Cladribine, floxuridine, fludarabine, hydroxyurea, ifosfamide, idarubicin, mesna, irinotecan, mitoxantrone, topotecan, leuprolide, megestrol, melphalan, mercaptopurine, plicamycin, mitotane, pegaspargase, pentostatin, pipobroman, plicamycin, streptozocin, tamoxifen, teniposide, testolactone, thioguanine, thiotepa, uracil mustard, vinorelbine, chlorambucil, and combinations thereof.

18. The method of claim 1 , wherein the oncological disorder is brain cancer.

Assignments (8)
SECURITY INTEREST Recorded Aug 29, 2025
From: BPGBIO INC.
To: BERG SURVIVOR’S TRUST; BERG, KARA ANN; THLIVERIS, ANDREW T.
Reel/Frame 072805/0303 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 8147825 WAS ADDED PREVIOUSLY RECORDED AT REEL: 70903 FRAME: 693. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Apr 30, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 071285/0001 →
SECURITY INTEREST Recorded Apr 21, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 070903/0693 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2023
From: BERG LLC
To: BPGBIO, INC.
Reel/Frame 063842/0405 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 4, 2022
From: NARAIN, NIVEN RAJIN; MCCOOK, JOHN PATRICK
To: CYTOTECH LABS, LLC
Reel/Frame 058545/0982 →
CHANGE OF NAME Recorded Jan 4, 2022
From: BERG PHARMA LLC
To: BERG LLC
Reel/Frame 058641/0193 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 4, 2022
From: BERG BIOSYSTEMS, LLC
To: BERG PHARMA LLC
Reel/Frame 058546/0018 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 4, 2022
From: CYTOTECH LABS, LLC
To: BERG BIOSYSTEMS, LLC
Reel/Frame 058546/0008 →
Continuity (10)
Continuation 16421788 · May 24, 2019
Continuation 15862856 · Jan 5, 2018
Continuation 14171419 · Feb 3, 2014
Continuation 12778094 · May 11, 2010
Provisional Application 61177245 · May 11, 2009
Provisional Application 61177246 · May 11, 2009
Provisional Application 61177244 · May 11, 2009
Provisional Application 61177243 · May 11, 2009
Provisional Application 61177241 · May 11, 2009
Related Publication 20220081720A1 · Mar 17, 2022
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