Ionization sources and methods and systems using them

1. An ionization source comprising:

an electron source; and

a multipolar rod assembly comprising a plurality of rods arranged substantially parallel to each other to form an ion volume from the substantially parallel arrangement of the plurality of rods, wherein the ion volume is configured to receive electrons from the electron source at a first end of the multipolar assembly and provide ionized analyte from the ion volume at a second end of the multipolar rod assembly, wherein the plurality of rods are configured to provide each of a magnetic field and a radio frequency field into the ion volume, wherein each rod of the multipolar rod assembly comprises a magnetizable material and is magnetized to provide a similar field strength, wherein the magnetic field provided by the plurality of rods is configured to constrain motion of the received electrons to an inner volume of the ion volume, and wherein the radio frequency field provided by the plurality of rods is configured to constrain analyte ions to the inner volume of the ion volume.

2. The ionization source of claim 1 , further comprising an enclosure surrounding or within the multipolar rod assembly, wherein the enclosure comprises an aperture fluidically coupled to the electron source at an inlet to permit the electrons from the electron source to enter into the ion volume through the inlet.

3. The ionization source of claim 1 , further comprising an ionization block comprising an entrance aperture and an exit aperture, wherein a longitudinal axis of each rod of the multipolar rod assembly is substantially parallel with a longitudinal axis of the ionization block, and wherein the entrance aperture is fluidically coupled to the ion volume to permit introduction of electrons through the entrance aperture and into the ion volume to ionize analyte within the ion volume, and wherein the exit aperture is configured to permit exit of ionized analyte from the ionization block.

4. The ionization source of claim 1 , further comprising an electron repeller arranged co-linearly with the electron source.

5. The ionization source of claim 1 , further comprising an electron reflector arranged co-linearly with the electron source and configured to receive electrons from the electron source.

6. The ionization source of claim 1 , wherein the multipolar rod assembly comprises at least four rods.

7. The ionization source of claim 1 , wherein a cross-sectional width of at least one rod of the multipolar rod assembly varies along a length of the at least one rod.

8. The ionization source of claim 1 , wherein at least two rods of the multipolar rod assembly comprise different shapes.

9. The ionization source of claim 1 , wherein the electron source comprises at least one filament, a field emitter or another electron source.

10. A mass spectrometer comprising:

the ionization source of claim 1 ; and

a mass analyzer fluidically coupled to the ion volume and configured to receive ionized analyte exiting the ion volume.

11. The mass spectrometer of claim 10 , further comprising a processor electrically coupled to a power source, wherein the processor is configured to provide a radio frequency voltage to rods of the multipolar rod assembly from the power source to provide the radio frequency field.

12. The mass spectrometer of claim 11 , wherein the processor is further configured to provide a DC voltage to rods of the multipolar rod assembly.

13. The mass spectrometer system of claim 11 , wherein the processor provides the radio frequency voltage to four rods of the multipolar assembly in a quadrupolar mode, to six rods of the multipolar assembly in a hexapolar mode, and to eight rods of the multipolar assembly in an octopolar mode.

14. The mass spectrometer of claim 10 , further comprising an electron reflector arranged co-linearly with the electron source and configured to receive electrons from the electron source.

15. A method of ionizing an analyte using a multipolar rod assembly, the method comprising:

introducing the analyte into an ion volume formed from a substantially parallel arrangement of rods of the multipolar rod assembly, wherein the ion volume is configured to receive electrons from an electron source, and wherein each rod of the multipolar rod assembly comprises a magnetizable material and is magnetized to provide a similar field strength; and

increasing ionization efficiency of the introduced analyte by constraining motion of the received electrons to an inner volume of the ion volume using a magnetic field provided by the multipolar rod assembly and constraining analyte ions to the inner volume using a radio frequency field provided by the multipolar rod assembly.

16. The method of claim 15 , wherein at least one rod of the multipolar rod assembly comprises a different magnetizable material than another rod of the multipolar rod assembly.

17. The method of claim 15 , further comprising reflecting the received electrons into the ion volume.