In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.
1. An implantable prosthesis comprising:
a tissue infiltratable scaffold of biocompatible material having a proximal end, a distal end spaced from the proximal end, and a core extending along a core axis from the proximal end to the distal end, the scaffold including:
a plurality of chambers circumferentially arranged around the core axis and extending in an outward radial direction away from the core, the plurality of chambers being arranged in two or more tiers of chambers stacked along the core axis between the proximal end and the distal end, each of the tiers of chambers including at least two chambers.
2. The implantable prosthesis according to claim 1 , wherein the plurality of chambers decrease in size in a direction of the core axis from the proximal end toward the distal end.
3. The implantable prosthesis according to claim 2 , wherein each of the tiers of chambers has an outer diameter, the outer diameter of each tier decreasing in the direction of the core axis from the proximal end to the distal end.
4. The implantable prosthesis according to claim 3 , wherein the two or more tiers includes a first tier of chambers located adjacent the proximal end, a second tier of chambers located adjacent the distal end and a third tier of chambers located between the first tier and the second tier.
5. The implantable prosthesis according to claim 4 , wherein the third tier has an outer diameter smaller than the first tier and the second tier has an outer diameter smaller than the third tier.
6. The implantable prosthesis according to claim 2 , wherein the chambers provided in each tier have the same size.
7. The implantable prosthesis according to claim 1 , wherein each of the plurality of chambers has a size which increases in the outward radial direction.
8. The implantable prosthesis according to claim 7 , wherein each of the plurality of chambers has a width which increases in the outward radial direction.
9. The implantable prosthesis according to claim 1 , wherein each of the plurality of chambers extends along a corresponding chamber axis in a direction transverse to the core axis.
10. The implantable prosthesis according to claim 9 , wherein the chamber axis for each of the plurality of chambers is different relative to each other chamber.
11. The implantable prosthesis according to claim 1 , wherein the scaffold has a frusto-conical shape.
12. The implantable prosthesis according to claim 1 , wherein the scaffold has a spherical shape.
13. The implantable prosthesis according to claim 1 , wherein the scaffold has a tubular shape.
14. The implantable prosthesis according to claim 1 , wherein the scaffold has a planar configuration at the proximal end and/or the distal end.
15. The implantable prosthesis according to claim 1 , further comprising a first layer of biocompatible material located at the proximal end of the scaffold and a second layer of biocompatible material located at the distal end of the scaffold, each of the first and second layers being oriented in a direction transverse to the core axis.
16. The implantable prosthesis according to claim 1 , wherein the scaffold is formed of absorbable material.
17. The implantable prosthesis according to claim 1 , wherein the scaffold is formed of mesh fabric.
18. The implantable prosthesis according to claim 17 , wherein the mesh fabric is tissue infiltratble.
19. The implantable prosthesis according to claim 1 , wherein the scaffold includes a plurality of sheets of mesh fabric.
20. The implantable prosthesis according to claim 19 , wherein the plurality of sheets of mesh fabric are connected together to form the plurality of chambers.
21. The implantable prosthesis according to claim 1 , wherein the scaffold is configured to augment and/or reconstruct an anatomical shape of a human breast.
22. The implantable prosthesis according to claim 15 , wherein the first and second layers are formed of absorbable material.
23. The implantable prosthesis according to claim 22 , wherein the first and second layers are formed of mesh fabric.
24. The implantable prosthesis according to claim 23 , wherein the mesh fabric is tissue infiltratable.
25. The implantable prosthesis according to claim 1 , wherein the plurality of chambers are tissue infiltratable.