In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.
1. An implantable prosthesis comprising:
a tissue infiltratable scaffold of biocompatible material having a proximal end and a distal end spaced from the proximal end, the scaffold including:
a plurality of scaffold segments located between the proximal and distal ends of the scaffold, the plurality of scaffold segments being arranged circumferentially about a longitudinal axis extending in a direction from the proximal end to the distal end, each of the plurality of scaffold segments extending in an outward radial direction away from the longitudinal axis and having an outer periphery extending from the proximal end to the distal end of the scaffold to define an outer profile of the scaffold; and
a plurality of chambers formed by the plurality of scaffold segments, the plurality of chambers circumferentially arranged around the longitudinal axis and extending in an outward radial direction away from the longitudinal axis,
the plurality of scaffold segments including first and second scaffold panels connected to each other at first and second connections located between the proximal end of the body and the longitudinal axis and spaced apart from each other in an axial direction parallel to the longitudinal axis.
2. The implantable prosthesis according to claim 1 , wherein each of the first and second connections is located adjacent the outer periphery of the respective scaffold segments.
3. The implantable prosthesis according to claim 2 , wherein the first and second scaffold panels are further connected together along a fold at the proximal end of the scaffold.
4. The implantable prosthesis according to claim 1 , wherein the first connection connects chambers located adjacent each other in the circumferential direction around the longitudinal axis.
5. The implantable prosthesis according to claim 1 , wherein the first connection connects chambers located adjacent each other in the axial direction.
6. The implantable prosthesis according to claim 1 , further comprising a first layer of biocompatible material attached to the proximal end of the scaffold and a second layer of biocompatible material attached to the distal end of the scaffold, the first and second layers being oriented in a direction transverse to the longitudinal axis.
7. The implantable prosthesis according to claim 6 , wherein the first and second layers are formed of absorbable material.
8. The implantable prosthesis according to claim 6 , wherein the first and second layers are formed of mesh fabric.
9. The implantable prosthesis according to claim 8 , wherein the mesh fabric is tissue infiltratable.
10. The implantable prosthesis according to claim 1 , wherein each of the plurality of chambers extends along a corresponding chamber axis which is transverse to the longitudinal axis.
11. The implantable prosthesis according to claim 10 , wherein each chamber axis extends in a different radial direction relative to each other.
12. The implantable prosthesis according to claim 11 , wherein the chamber axis of each of the plurality of chambers is oriented at an angle relative to the proximal end, the angle of the chamber axis being the same for each chamber in a first group of chambers.
13. The implantable prosthesis according to claim 10 , wherein each of the plurality of chambers is open in the corresponding outward radial direction.
14. The implantable prosthesis according to claim 1 , wherein each of the plurality of chambers has a size which increases in the outward radial direction.
15. The implantable prosthesis according to claim 14 , wherein each of the plurality of chambers has a width which increases in the outward radial direction.
16. The implantable prosthesis according to claim 1 , wherein the scaffold has a frusto-conical shape.
17. The implantable prosthesis according to claim 1 , wherein the scaffold has a spherical shape.
18. The implantable prosthesis according to claim 1 , wherein the scaffold has a tubular shape.
19. The implantable prosthesis according to claim 1 , wherein the scaffold has a planar configuration at the proximal end and/or the distal end.
20. The implantable prosthesis according to claim 1 , wherein the scaffold is formed of absorbable material.
21. The implantable prosthesis according to claim 1 , wherein the scaffold is formed of mesh fabric.
22. The implantable prosthesis according to claim 21 , wherein the mesh fabric is tissue infiltratable.
23. The implantable prosthesis according to claim 1 , wherein the plurality of chambers are tissue infiltratable.
24. The implantable prosthesis according to claim 1 , wherein the scaffold is configured to augment and/or reconstruct an anatomical shape of a human breast.