In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material

1. A method of fabricating an implantable prosthesis, the method comprising acts of:

(a) providing a plurality of sheets of biocompatible material;

(b) folding one of the plurality of sheets along a first fold to form a scaffold segment including at least two scaffold panels;

(c) repeating act (b) for each of the plurality of sheets to form a plurality of scaffold segments; and

(d) arranging the plurality of scaffold segments circumferentially about a longitudinal axis to form an implantable scaffold having a three-dimensional configuration with the scaffold panels forming a plurality of chambers facing outwardly and extending in an outward radial direction away from the longitudinal axis.

2. The method according to claim 1 , wherein act (d) includes forming a hollow core about the longitudinal axis, the plurality of scaffold segments being arranged about and extending outwardly in a direction away from the hollow core.

3. The method according to claim 2 , further comprising an act (e) of attaching a first layer of biocompatible material to a proximal end of the scaffold.

4. The method according to claim 3 , wherein the first layer includes an opening, act (d) includes forming an opening at a proximal end of the hollow core, and act (e) includes aligning the opening in the first layer with the opening at the proximal end of the hollow core.

5. The method according to claim 3 , further comprising an act (f) of attaching a second layer of biocompatible material to a distal end of the scaffold which is spaced from the proximal end of the scaffold.

6. The method according to claim 5 , wherein the second layer includes an opening, act (d) includes forming an opening at a distal end of the hollow core, and and act (f) includes aligning the opening in the second layer with the opening at the distal end of the hollow core.

7. The method according to claim 1 , wherein act (d) includes attaching adjacent scaffold segments to each other to form the plurality of chambers.

8. The method according to claim 7 , wherein act (d) includes connecting a side of a first chamber to a side of a second chamber.

9. The method according to claim 8 , wherein act (d) includes connecting a top of the first chamber to a bottom of a third chamber.

10. The method according to claim 7 , wherein act (d) includes connecting adjacent scaffold segments to each other at first and second connections located between a proximal end of the scaffold and a distal end of the scaffold and spaced apart from each other in an axial direction parallel to the longitudinal axis.

11. The method according to claim 1 , wherein act (d) includes forming a plurality of first chambers having a first shape and a plurality of second chambers having a second shape which is different from the first shape.

12. The method according to claim 11 , wherein act (d) includes forming each of the plurality of first chambers with an oval shape and each of the plurality of second chambers with a non-oval shape.

13. The method according to claim 12 , wherein act (d) includes forming each of the plurality of second chambers with a diamond-like shape.

14. The method according to claim 1 , wherein act (d) includes forming a plurality of first chambers having a first size and a plurality of second chambers having a second size which is different from the first size.

15. The method according to claim 14 , wherein act (d) includes forming each of the plurality of chambers with a size which increases in the outward radial direction.

16. The method according to claim 15 , wherein act (d) includes forming each of the plurality of chambers with a width which increases in the outward radial direction.

17. The method according to claim 1 , wherein the implantable prosthesis is configured to augment and/or reconstruct an anatomical shape of a human breast.