Atraumatically formed tissue compositions, devices and methods of preparation and treatment
A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.
1. A method of treating a patient comprising:
extracting a full thickness skin graft from the patient;
forming full thickness skin graft morsels by repeatedly atraumatically slicing the extracted full thickness skin graft in a solution using a system comprising:
an aseptic container,
an atraumatic cutting device supported within said container, said cutting device forming full thickness skin graft morsels while maintaining viability of the morsels;
an opening in the container for fluidly communicating with a detachable dispensing device; and
a detachable dispensing device for receiving the morsels;
a filter device for separating the solution from the morsels;
wherein the thus formed morsels travel through the opening in the container and into the dispensing device; and
applying the morsels to a portion of the patient's body to be treated using the dispensing device.
2. The method of claim 1 , wherein the filter device includes a filter.
3. The method of claim 1 , wherein the fluid is filtered from the morsels prior to application to the wound.
4. The method of claim 1 , wherein a predominant amount of the skin cells remain viable.
5. The method of claim 1 , wherein the donor cite is then closed by sutures, staples, adhesives or a combination thereof.
6. The method of claim 1 , wherein formation of the morsels in the device occurs in about 1 to about 10 minutes.
7. The method of claim 1 , wherein the donor site is from the abdomen of a patient.
8. The method of claim 1 , wherein the dispensing device is a syringe.
9. The method of claim 1 , wherein the solution includes a component selected from the group consisting of growth factors, a drug, fibrin glue, autologous platelet rich plasma and combinations thereof.
10. The method of claim 1 , wherein the portion of the patient's body to be treated is a wound.
11. The method of claim 1 , wherein the portion of the patient's body to be treated is an organ.
12. The method of claim 1 , wherein the portion of the patient's body to be treated is cosmetic.
13. The method of claim 1 wherein said solution is a saline-containing solution.
14. The method of claim 1 wherein the solution is selected from a saline-containing solution, an isotonic compatible medium capable of buffering pH and combinations thereof.