Regulatory T cell epitopes, compositions and uses thereof
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epitopes of the invention.
1. A method of inducing regulatory T-cells to suppress immune response in a subject comprising administrating to the subject a therapeutically effective amount of a T-cell epitope composition, wherein the T-cell epitope composition comprises one or more isolated T-cell epitope polypeptides, wherein at least one isolated T-cell epitope polypeptide consists of the amino acid sequence of SEQ ID NO: 12.
2. The method of claim 1 , wherein the T-cell epitope composition further comprises at least one isolated T-cell epitope polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS: 6, 8-11, 13-22, 24-30, and 32-58.
3. The method of claim 1 , wherein the T-cell epitope composition further comprises at least one isolated T-cell epitope polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS: 6, 10, 14, 15, 24, or 25.
4. The method of claim 1 , wherein the T-cell epitope composition further comprises an effective amount of one or more antigens and/or allergens.
5. The method of claim 1 , wherein the immune suppressive effect is mediated by natural regulatory T-cells.
6. The method of claim 1 , wherein the immune suppressive effect is mediated by adaptive regulatory T-cells.
7. The method of claim 1 , wherein the T-cell epitope composition suppresses an effector T-cell response.
8. The method of claim 7 , wherein the T-cell epitope composition suppresses a cytokine secretion of effector T-cells.
9. The method of claim 1 , wherein the T-cell epitope composition suppresses a helper T-cell response.
10. The method of claim 1 , wherein the T-cell epitope composition suppresses a B-cell response.