Endovascular Prostheses
Low profile, self-expanding endovascular prostheses having a Ni-Ti alloy stent structure that is particularly well-suited for accessing and traversing narrow anatomical passageways and providing physiologically acceptable radial or hoop strength and longitudinal flexibility.
1 . An endovascular prosthesis, comprising:
a single linear wire stent structure, said wire stent structure comprising a nickel-titanium (Ni-Ti) alloy,
said wire stent structure further comprising a superelastic structure, wherein said wire stent structure is adapted to transition from a pre-deployment configuration, wherein said stent structure can be disposed in a delivery catheter, to an expanded post-deployment coil configuration when said wire stent structure is subjected to a pre-defined temperature,
said wire stent structure further comprising an outer coating, said outer coating comprising an extracellular matrix (ECM) composition comprising acellular ECM derived from a mammalian tissue source.
2 . The endovascular prosthesis of claim 1 , wherein said mammalian tissue source is selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS), urinary basement membrane (UBM), liver basement membrane (LBM), stomach submucosa (SS), mesothelial tissue, placental tissue, and cardiac tissue.
3 . The endovascular prosthesis of claim 1 , wherein said ECM composition further comprises at least one exogenously added biologically active agent.
4 . The endovascular prosthesis of claim 3 , wherein said biologically active agent comprises a cell selected from the group consisting of a human embryonic stem cell, fetal cardiomyocyte, myofibroblast, and mesenchymal stern cell.
5 . The endovascular prosthesis of claim 3 , wherein said biologically active agent comprises a growth factor selected from the group consisting of a transforming growth factor-alpha (TGF-α), transforming growth factor-beta (TGF-β), fibroblast growth factor-2 (FGF-2), and vascular endothelial growth factor (VEGF).
6 . The endovascular prosthesis of claim 1 , wherein said ECM composition further comprises a pharmacological agent.
7 . The endovascular prosthesis of claim 6 , wherein said pharmacological agent comprises an agent selected from the group consisting of an antibiotic, anti-viral agent, analgesic, anti-inflammatory, anti-neoplastic, anti-spasmodic, and anticoagulant and antithrombotic agent.