Method and Composition for Enhancing the Quality and Benefits of Sleep
Compounds, compositions and methods of making and using for enhancing the quality and benefit of sleep and/or wakefulness in a subject in need thereof.
1 . A composition comprising an effective amount of magnesium di-L-theanate, wherein the effective amount is sufficient to decrease sleep latency, increase length of sleep, increase brain wave amplitude, decrease spike frequency of electrical activity disrupting sleep, restore concentrations of key brain neurotransmitters, restore and maintain functionality of brain neurotransmitters, reduce adverse effects of stress, reduce oxidative stress, reduce metabolic disruption of a subject's brain, and combinations thereof.
2 . The composition of claim 1 , wherein the composition is formulated for administration to a mammal.
3 . The composition of claim 2 , wherein the composition is an oral formulation.
4 . The composition of claim 3 , wherein the composition is a dietary supplement, nutritional supplement or a nutraceutical.
5 . The composition of claim 4 , wherein the composition comprises at least one excipient.
6 . The composition of claim 5 , wherein the composition is formulated for one or more doses per 24 hour period.
7 . The composition of claim 6 , wherein the composition is formulated for administration for more than one day.
8 . A method of improving sleep in a subject in need thereof, the method comprising the step of administering a composition comprising an effective amount of di-L-theanate, wherein the effective amount is sufficient to decrease sleep latency, increase length of sleep, increase brain wave amplitude, decrease spike frequency of electrical activity disrupting sleep, restore concentrations of key brain neurotransmitters, restore and maintain functionality of brain neurotransmitters, reduce adverse effects of stress, reduce oxidative stress, reduce metabolic disruption of a subject's brain, and combinations thereof.
9 . The method of claim 8 , wherein the composition is formulated for administration to a mammal.
10 . The method of claim 9 , wherein the composition is an oral formulation.
11 . The method of claim 10 , wherein the composition is a dietary supplement, nutritional supplement or a nutraceutical.
12 . The method of claim 11 , wherein the composition comprises at least one excipient.
13 . The method of claim 12 , wherein the composition is formulated for one or more doses per 24 hour period.
14 . The method of claim 13 , wherein the composition is formulated for administration for more than one day.
15 . A method of making the magnesium di-L-theanate of claim 1 , wherein the method comprises using absolute ethanol.
16 . A method of making the magnesium di-L-theanate of claim 1 , wherein the method comprises using methanol and water.
17 . A method of making the magnesium di-L-theanate of claim 1 , wherein the method comprises using magnesium oxide.
18 . A method of making the magnesium di-L-theanate of claim 1 , wherein the method comprises using an exchange reaction.
19 . A compound comprising magnesium di-L-theanate.