IP Library Granted Patent US 11,666,516
Granted Patent B2
US 11,666,516 · App. 17/250,351 · Granted Jun 6, 2023

Aqueous oral care thiocyanate-containing compositions, methods, and kits

Inventors: Yizhong Wang (Woodbury, MN); Ta-Hua Yu (Woodbury, MN); Joel D. Oxman (Minneapolis, MN); Richard P. Rusin (Woodbury, MN)
Assignee: 3M INNOVATIVE PROPERTIES COMPANY
A61K8/21A61K8/46A61Q11/00A61Q11/02A61K2800/5424A61K2800/5426A61K2800/92
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Quick Facts
Patent No.
US 11,666,516
App. No.
17/250,351
Granted
Jun 6, 2023
Kind
B2
Abstract

An aqueous oral care one-part composition (e.g., solution), a kit that includes such composition (e.g., solution), and methods (e.g., a method of providing fluoride to a patients tooth surface), wherein the oral care composition (e.g., solution) includes: silver cations; thiocyanate anions; fluoride anions; and water.

Claims (27)

1. An aqueous oral care one-part composition comprising:

silver cations;

thiocyanate anions;

fluoride anions; and

water;

wherein the molar ratio of silver to thiocyanate ions is less than 0.37:1, and water is less than 57.1 wt-%, based on the total weight of the composition.

2. The oral care one-part composition of claim 1 comprising:

12.2-20 wt-% silver cations; and

2.0-4.0 wt-% fluoride anions;

wherein the weight percentages are based on the total weight of the composition;

wherein the molar ratio of silver to thiocyanate ions is at least 0.1:1 and less than 0.37:1; and

wherein the oral care composition forms a precipitate upon contact with additional water or saliva.

3. The oral care one-part composition of claim 1 or 2 comprising:

12.2-20 wt-% silver cations;

thiocyanate anions; and

2.2-3.5 wt-% fluoride anions.

4. The oral care one-part composition of claim 1 :

a source of silver cations selected from silver fluoride, silver chloride, silver nitrate, silver iodide, silver diamine fluoride, and combinations thereof; and

a source of fluoride anions selected from silver fluoride, silver diamine fluoride, sodium fluoride, ammonium fluoride, potassium fluoride, amine fluoride, and combinations thereof.

5. The oral care one-part composition of claim 1 comprising a source of thiocyanate anions selected from ammonium thiocyanate, sodium thiocyanate, potassium thiocyanate, guanidinium thiocyanate, and combinations thereof.

6. A method of providing fluoride to a patient's tooth surface, the method comprising applying the aqueous oral care one-part composition of claim 1 .

7. A method of reducing the incidence of dental caries in a patient in need thereof, the method comprising applying an aqueous oral care one-part composition of claim 1 to the patient's tooth surface.

8. A method of reducing dentin sensitivity and/or root sensitivity in a patient in need thereof, the method comprising applying an aqueous oral care one-part composition of claim 1 to the patient's tooth surface.

9. A method of treating a patient's tooth surface, the method comprising:

applying an aqueous oral care one-part composition to the patient's tooth surface; wherein the aqueous oral care one-part composition comprises: silver cations; thiocyanate anions; fluoride anions; and water; and

optionally, applying a dental restorative to the treated tooth surface.

10. A kit comprising an aqueous oral care one-part composition of claim 1 and an applicator.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2024
From: 3M INNOVATIVE PROPERTIES COMPANY
To: SOLVENTUM INTELLECTUAL PROPERTIES COMPANY
Reel/Frame 066435/0347 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2021
From: WANG, YIZHONG; YU, TA-HUA; OXMAN, JOEL D.; RUSIN, RICHARD P.
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 054858/0472 →
Continuity (2)
Provisional Application 62703976 · Jul 27, 2018
Related Publication 20210290501A1 · Sep 23, 2021