IP Library › Granted Patent US 12,577,593
Granted Patent B2
US 12,577,593 · App. 17/253,944 · Granted Mar 17, 2026

DHA enriched polyunsaturated fatty acid compositions

Inventor: Stuart Littler (Clayton, AU)
Assignee: Nuseed Nutritional US Inc.
C12P7/6472A23D7/00A23D9/00A61K31/202C12P7/6458
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Quick Facts
Patent No.
US 12,577,593
App. No.
17/253,944
Granted
Mar 17, 2026
Kind
B2
Abstract

There is provided a vegetable-based lipid composition comprising high levels of at least three different long-chain polyunsaturated fatty acids (typically as fatty acid esters). The compositions contain DHA as the principal long-chain polyunsaturated fatty acid. The composition is obtainable from a single source by conventional processing methods, and has improved stability properties.

Claims (21)

1 . A vegetable-based lipid composition comprising:

(i) docosahexaenoic acid (22:6n-3) (DHA) in an amount of from 50% to 85% by weight of the total fatty acid content of the composition;

(ii) a second polyunsaturated fatty acid in an amount of from 10% to 90% by weight of the DHA; and

(iii) a third polyunsaturated fatty acid in an amount of from 10% to 70% by weight of the second polyunsaturated fatty acid;

wherein the total amount of all other fatty acids in the composition is up to 20% by weight of the total fatty acid content of the composition, wherein the second or third polyunsaturated fatty acid is eicosatetraenoic acid (20:4n-3) (ETA), wherein each of the docosahexaenoic acid, and the second and third polyunsaturated fatty acids is independently provided in the form of a fatty acid, a fatty acid salt, a fatty acid ester or a salt of a fatty acid ester; wherein the amount of eicosapentaenoic acid (EPA) in the composition is less than 10% by weight of the amount of DHA, wherein the ratio of omega-3 fatty acids to omega-6 fatty acids in the composition is at least 10:1, wherein the composition contains less than 0.5% palmitic acid (C16:0) by weight of the total fatty acid in the composition; and wherein the lipids present in the composition are obtained from plant sources.

2 . The lipid composition of claim 1 , wherein the docosahexaenoic acid is present in an amount that is at least 55% by weight of the total fatty acid content of the composition.

3 . The lipid composition of claim 1 , wherein the second polyunsaturated fatty acid is present in an amount of from 10% to 60% by weight of the docosahexaenoic acid.

4 . The lipid composition of claim 1 , wherein the second polyunsaturated fatty acid is a C18-24 omega-3 polyunsaturated fatty acid containing at least three unsaturations.

5 . The lipid composition of claim 1 , wherein the third polyunsaturated fatty acid is present in an amount of from 10% to 65% by weight of the second polyunsaturated fatty acid.

6 . The lipid composition of claim 1 , wherein the third polyunsaturated fatty acid is a C18-24 omega-3 polyunsaturated fatty acid containing at least three unsaturations.

7 . The lipid composition of claim 1 , wherein the DHA and the second and third polyunsaturated fatty acids are each independently provided in the form of a fatty acid ester or a salt of a fatty acid ester, wherein the fatty acid ester or salt of the fatty acid ester is a fatty acid ethyl ester or part of a triglyceride.

8 . The lipid composition of claim 1 , wherein the lipid composition is derived from a single source.

9 . The lipid composition of claim 1 , wherein the plant-based oil is from an oilseed selected from Brassica sp., Gossypium hirsutum, Limum usitatissimum, Helianthus sp., Carthamus tinctorius, Glycine max, Zea mays, Arabidopsis thaliana, Sorghum bicolor, Sorghum vulgare, Avena sativa, Trifolium sp., Elaeis guineensis, Nicotiana benthamiana, Hordeum vulgare, Lupimis angustifolius, Oryza sativa, Oryza glaberrima, Camelina sativa , or Crambe abyssinica.

10 . The lipid composition of claim 1 , wherein the composition is provided in the form of a tablet, capsule, encapsulated gel, ingestible liquid or powder, emulsion, or a topical ointment or cream.

11 . The lipid composition of claim 1 , further comprising one or more additional components selected from the group consisting of an antioxidant, a stabiliser and a surfactant.

12 . A nutraceutical composition comprising the lipid composition of claim 1 .

13 . A food product for human or animal consumption comprising the lipid composition of claim 1 , wherein the DHA and the second and third polyunsaturated fatty acids are provided in the form of triglyceride esters.

14 . The vegetable-based lipid composition of claim 1 for use in the treatment or prevention of cardiovascular disease, protection against death in patients with cardiovascular disease, reduction of overall serum cholesterol levels, reduction in high blood pressure, increase in HDL:LDL ratio, reduction of triglycerides, or reduction of apolipoprotein-B levels.

15 . A method for producing the vegetable-based lipid composition of claim 1 , comprising providing a mixture of fatty acid ethyl esters, and subjecting said mixture to a chromatographic separation process, optionally wherein the mixture of fatty acid ethyl esters is obtained by transesterification and distillation of a vegetable-based lipid oil.

16 . The lipid composition of claim 4 , wherein said C18-24 omega-3 polyunsaturated fatty acid containing at least three unsaturations is α-linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3), docosapentaenoic acid (22:5n-3), or stearadonic acid (18:4n-3).

17 . The lipid composition of claim 6 , wherein said C18-24 omega-3 polyunsaturated fatty acid containing at least three unsaturations is α-linolenic acid (18:3n-3), eicosapentaenoic acid (20:5n-3), eicosatetraenoic acid (20:4n-3), docosapentaenoic acid (22:5n-3), or stearadonic acid (18:4n-3).

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2023
From: LITTLER, STUART
To: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Reel/Frame 062388/0896 →
SECURITY INTEREST Recorded Dec 5, 2022
From: NUFARM AMERICAS, INC.; NUSEED AMERICAS, INC.; NUSEED NUTRITIONAL US INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 061972/0303 →
SECURITY INTEREST Recorded Dec 5, 2022
From: NUFARM AMERICAS, INC.; NUSEED AMERICAS, INC.; NUSEED NUTRITIONAL US INC.
To: ANZ FIDUCIARY SERVICES PTY LTD
Reel/Frame 061972/0332 →
SECURITY INTEREST Recorded Nov 22, 2022
From: NUFARM AMERICAS, INC.; NUSEED AMERICAS INC.; NUSEED NUTRITIONAL US INC.
To: ANZ FIDUCIARY SERVICES PTY LTD
Reel/Frame 061853/0142 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2021
From: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
To: NUSEED PTY LTD.
Reel/Frame 057494/0923 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2021
From: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
To: NUSEED PTY LTD.
Reel/Frame 057429/0892 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 28, 2021
From: NUSEED AMERICAS INC.
To: NUSEED NUTRITIONAL US INC.
Reel/Frame 056686/0116 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 28, 2021
From: NUSEED PTY LTD.
To: NUSEED AMERICAS INC.
Reel/Frame 056685/0888 →
Priority Claims (1)
EP 18179080 · Jun 21, 2018 · regional
Continuity (1)
Related Publication 20210254110A1 · Aug 19, 2021
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