Use of riluzole prodrugs to treat alzheimer's disease
Disclosed are methods of treating Alzheimer's Disease by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
1. A method of treating Alzheimer's Disease in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a riluzole prodrug, wherein the riluzole prodrug has the following formula:
or a pharmaceutically acceptable salt thereof, and
wherein the riluzole prodrug is adminstered to the patient at a dosage of from about 100 to 400 mg per day.
2. The method of claim 1 , wherein the riluzole prodrug is administered to the patient at a dosage of about 110, or 140, or 150, or 210, or 280, or 350 mg per day.
3. The method of claim 2 , wherein the riluzole prodrug is administered to the patient at a dosage of 280 mg, once per day.
4. The method of claim 3 , wherein the riluzole prodrug is administered to the patient at a dosage of 140 mg, twice per day.
5. The method of claim 1 , wherein the riluzole prodrug is administered to the patient once per day.
6. The method of claim 1 , wherein the riluzole prodrug is administered to the patient twice per day.
7. The method of claim 1 , wherein the riluzole prodrug is administered to the patient in the form of a capsule.
8. The method of claim 1 , wherein the riluzole prodrug is administered to the patient in the form of a tablet.
9. The method of claim 1 , wherein the riluzole prodrug is administered to the patient for a duration of from about 8 weeks to 48 weeks.
10. The method of claim 1 , wherein the riluzole prodrug is administered to the patient for a duration of from the onset of treatment to the end of the patient's life.
11. A method for improving a response in a patient afflicted with Alzheimer's disease comprising administering to the patient in need thereof, an effective amount of a riluzole prodrug,
wherein the riluzole prodrug has the following formula:
or a pharmaceutically acceptable salt thereof, and
wherein the riluzole prodrug is administered to the patient at a dosage of from about 100 to 400 mg per day.
12. The method of claim 11 , wherein the improved response is one or more of overall survival, quality of life, overall response rate, duration of response, delay of onset, or patient reported outcome.
13. A kit for treating a patient afflicted with Alzheimer's Disease, the kit comprising:
(a) a riluzole prodrug; and
(b) instructions for administering the riluzole prodrug in the method of claim 1 ,
wherein the riluzole prodrug has the following formula:
or a pharmaceutically acceptable salt thereof, and
wherein the riluzole prodrug is administered to the patient at a dosage of from about 100 to 400 mg per day.