Intraluminal device with wire braiding configuration
Intraluminal devices and methods of fabricating intraluminal devices may be provided. In one implementation, an intraluminal device may be formed of a plurality of wires and may include a distal coil, a proximal coil, and an expandable mesh segment positioned between the distal and proximal coils. The distal coil, proximal coil, and expandable mesh segment may be formed as a single, unitary structure, with at least one wire of the plurality of wires extending continuously from the proximal coil to the distal coil.
1 . An intraluminal device including an elongated body formed of a plurality of wires, the intraluminal device comprising:
a first region wherein the plurality of wires are twisted to form a first cable;
a second region, distal to the first region, in which the plurality of wires are woven to form an expandable mesh segment which is configured to capture a blood clot; and
a third region distal to the second region and forming a distal tip of the elongated body, wherein the plurality of wires in the third region are twisted to form a second cable,
wherein one or more of the plurality of wires is cut along the elongated body at a transition between the first region and the second region, the first region comprising more wires than the second region;
wherein other wires of the plurality of wires extend through the transition, twisted wires transitioning to be woven together, a wire pattern in the transition providing the transition with an outer profile free of exposed ends of wires;
wherein the third region is formed of one or more wires of the plurality of wires which extend continuously from the first region to the distal tip of the elongated body;
wherein the first region of the intraluminal device, the second region of the intraluminal device, and the third region of the intraluminal device are together formed as a single unitary structure without connections or attachments to the plurality of wires in an adjacent region; and
wherein lack of connections and attachments and lack of exposed ends of wires provide the intraluminal device with a smooth outer profile;
wherein the weave pattern of the plurality of wires in the transition includes crossing and/or bending of wires to embed cut ends of the one or more cut wires within the intraluminal device.
2 . The intraluminal device of claim 1 , wherein the expandable mesh segment includes:
at least one expandable filter segment in which the plurality of wires are woven to form a first weave pattern, the first weave pattern having an opening therein formed between two or more wires; and
at least one expandable clot capture zone in which the plurality of wires are woven to form a second weave pattern, the second weave pattern being different from the first weave pattern and having an opening therein formed between two or more wires,
wherein, in an expanded configuration, the opening of the at least one clot capture zone is larger than the opening of the at least one filter segment.
3 . The intraluminal device of claim 2 , wherein the plurality of wires in the at least one clot capture zone are grouped into a plurality of wire groupings in the at least one clot capture zone, wherein each wire grouping of the plurality of wire groupings includes at least two wires and forms an intertwined wire combination.
4 . The intraluminal device of claim 3 , wherein the opening of the at least one clot capture zone is formed between at least two of the intertwined wire combinations.
5 . The intraluminal device of claim 3 , wherein each wire grouping of the plurality of wire groupings includes two wires, three wires, or four wires.
6 . The intraluminal device of claim 2 , wherein the at least one expandable filter segment is configured to capture smaller clots than the at least one expandable clot capture zone.
7 . The intraluminal device of claim 2 , wherein
the at least one expandable filter segment includes: a first filter segment and a second filter segment, the second filter segment being distal to the first filter segment; and
the at least one expandable clot capture zone includes:
a first clot capture zone positioned between the first filter segment and the third region of the intraluminal device; and
a second clot capture zone positioned between the second filter segment and the first region of the intraluminal device.
8 . The intraluminal device of claim 1 , wherein the plurality of wires consists of at least one of a set of: eight wires, ten wires, and twelve wires.
9 . The intraluminal device of claim 1 , wherein at least one wire of the plurality of wires has a diameter between 40 microns and 55 microns.
10 . The intraluminal device of claim 9 , wherein the at least one wire has a diameter of 40 microns, 45 microns, 50 microns, or 55 microns.
11 . The intraluminal device of claim 1 , further comprising at least one radiopaque marker positioned at a point along the elongated body, the point along the elongated body being at least one of: a point distal to the second region and a point proximal of the second region.
12 . The intraluminal device of claim 1 , wherein each of the plurality of wires passes continuously through transition regions of the intraluminal device without forming interruptions or gaps.
13 . The intraluminal device of claim 1 , wherein the one or more of the plurality of wires of the second region is cut along the elongated body at a transition between the second region and the third region.
14 . The intraluminal device of claim 1 , wherein the third region, having fewer wires than the first region, is softer and more pliable than the first region.
15 . The intraluminal device of claim 14 , wherein the fewer wires of the third region are twisted with a smaller cable coiling angle than the first region, providing the softer more pliable third region.
16 . A method of manufacturing an intraluminal device including an elongated body formed of a plurality of wires, the method comprising:
twisting a plurality of wires upon a first segment of a mandrel so as to form a first cable of the elongated body;
cutting at least one of the plurality of wires;
weaving the plurality of wires upon a second segment of the mandrel so as to form an expandable mesh segment of the elongated body which is configured to capture a blood clot; and
twisting the plurality of wires upon a third segment of the mandrel so as to form a second cable of the elongated body, the second cable including a region that forms a distal tip of the elongated body;
wherein the cutting at least one of the plurality of wires is along the elongated body at a transition between the first cable and the expandable mesh segment, the first cable comprising more wires than the expandable mesh segment;
wherein the weaving at the transition is configured to provide a device outer profile free of exposed ends of wires, the weave pattern of the plurality of wires in the transition including crossing and/or bending of wires to embed cut ends of the at least one cut wires within the intraluminal device;
wherein the second segment of the mandrel is positioned between the first segment of the mandrel and the third segment of the mandrel, and wherein the plurality of wires are braided continuously along the mandrel as a single unitary structure without connections or attachments to the plurality of wires in an adjacent region; and
wherein lack of connections and attachments and lack of exposed ends of wires provide the intraluminal device with a smooth outer profile.
17 . The method of claim 16 , further comprising heat-treating the expandable mesh segment.
18 . The method of claim 16 , wherein the second segment of the mandrel has a larger diameter than the first segment of the mandrel and the third segment of the mandrel.
19 . The method of claim 16 , wherein the plurality of wires consists of at least one of a set of: eight wires, ten wires, and twelve wires.
20 . The method of claim 16 , wherein at least one wire of the plurality of wires has a diameter between 40 microns and 55 microns.