Diagnostic drug and diagnostic method for Alzheimer's disease
The present invention provides a polypeptide consisting of any of the following amino acid sequences and useful for determining Alzheimer's disease: (1) the amino acid sequence shown in SEQ ID NO: 1; and (2) an amino acid sequence resulting from substitution, deletion, addition or insertion of one to several amino acids in the amino acid sequence shown in SEQ ID NO: 1.
1. An antibody recognizing a S38AA polypeptide, wherein the S38AA polypeptide consists of the amino acid sequence of SEQ ID NO: 1, or an amino acid sequence resulting from substitution, deletion, addition, or insertion of one to several amino acids in the amino acid sequence of SEQ ID NO: 1, and wherein the antibody is
(a) an antibody comprising the heavy chain variable region of SEQ ID NO: 4, and the light chain variable region of SEQ ID NO: 5,
(b) an antibody comprising the heavy chain variable region of SEQ ID NO: 6, and the light chain variable region of SEQ ID NO: 7,
(c) an antibody comprising the heavy chain variable region of SEQ ID NO: 8, and the light chain variable region of SEQ ID NO: 9,
(d) an antibody comprising the heavy chain variable region of SEQ ID NO: 10, and the light chain variable region of SEQ ID NO: 11,
(e) an antibody comprising the heavy chain variable region of SEQ ID NO: 12, and the light chain variable region of SEQ ID NO: 13,
(f) an antibody comprising the heavy chain variable region of SEQ ID NO: 14, and the light chain variable region of SEQ ID NO: 15,
(g) an antibody comprising the heavy chain variable region of SEQ ID NO: 16, and the light chain variable region of SEQ ID NO: 17,
(h) an antibody comprising the heavy chain variable region of SEQ ID NO: 18, and the light chain variable region of SEQ ID NO: 19,
(i) an antibody comprising the heavy chain variable region of SEQ ID NO: 20, and the light chain variable region of SEQ ID NO: 21, or
(j) an antibody comprising the heavy chain variable region of SEQ ID NO: 22, and the light chain variable region of SEQ ID NO: 23.
2. The antibody of claim 1 , further recognizing the polypeptide of SEQ ID NO: 2.
3. The antibody of claim 1 , wherein the S38AA polypeptide consists of the amino acid sequence of SEQ ID NO: 1.
4. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 4, and the light chain variable region of SEQ ID NO: 5.
5. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 6, and the light chain variable region of SEQ ID NO: 7.
6. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 8, and the light chain variable region of SEQ ID NO: 9.
7. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 10, and the light chain variable region of SEQ ID NO: 11.
8. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 12, and the light chain variable region of SEQ ID NO: 13.
9. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 14, and the light chain variable region of SEQ ID NO: 15.
10. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 16, and the light chain variable region of SEQ ID NO: 17.
11. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 18, and the light chain variable region of SEQ ID NO: 19.
12. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 20, and the light chain variable region of SEQ ID NO: 21.
13. The antibody of claim 1 , wherein the antibody is an antibody comprising the heavy chain variable region of SEQ ID NO: 22, and the light chain variable region of SEQ ID NO: 23.
14. An agent for determining Alzheimer's disease or the progression of Alzheimer's disease in a subject, comprising the antibody of claim 1 .
15. A kit comprising the antibody of claim 1 .
16. The kit of claim 15 , further comprising a S38AA polypeptide, wherein the S38AA polypeptide consists of the amino acid sequence of SEQ ID NO: 1, or an amino acid sequence resulting from substitution, deletion, addition, or insertion of one to several amino acids in the amino acid sequence of SEQ ID NO: 1.
17. A method for detecting a S38AA polypeptide, wherein the S38AA polypeptide consists of the amino acid sequence of SEQ ID NO: 1, or an amino acid sequence resulting from substitution, deletion, addition, or insertion of one to several amino acids in the amino acid sequence of SEQ ID NO: 1, which method comprises a step of contacting a test sample with the antibody of claim 1 .