Combination vaccine
View Patent ↗The present invention pertains to a vaccine comprising (a) an immunologically effective amount of a Streptococcus suis IgM protease antigen, (b) an immunologically effective amount of an Escherichia coli fibmrial antigen, and (c) an immunologically effective amount of a Clostridium toxoid, and also pertains to use of the vaccine in a method for protecting pigs against a pathogenic infection with Streptococcus suis, Escherichia coli and Clostridium.
1. A vaccine comprising components (a), (b) and (c) of:
(a) an immunologically effective amount of a Streptococcus suis IgM protease antigen,
(b) an immunologically effective amount of an Escherichia coli fimbrial antigen, and
(c) an immunologically effective amount of a Clostridium toxoid.
2. The vaccine according to claim 1 , characterized in that component (b) comprises one or more Escherichia coli fimbrial antigens selected from F4, F5, F6, F18, and F41.
3. The vaccine according to claim 2 , characterized in that component (b) comprises at least the fimbrial Escherichia coli antigens F4, F5 and F6.
4. The vaccine according to claim 1 , characterized in that component (b) further comprises an Escherichia coli toxoid.
5. The vaccine according to claim 4 , characterized in that the Escherichia coli toxoid is Escherichia coli LT toxoid.
6. The vaccine according to claim 1 , characterized in that component (c) comprises Clostridium perfringens Type C toxoid.
7. The vaccine according to claim 6 , characterized in that component (c) further comprises Clostridium perfringens Type B toxoid.
8. The vaccine according to claim 1 , characterized in that component (b) comprises the Escherichia coli fimbrial antigens F4, F5, and F6 and component (c) comprises the Clostridium perfringens type C toxoid.
9. The vaccine according to claim 1 , characterized in that the vaccine comprises an adjuvant.
10. The vaccine according to claim 1 , characterized in that the vaccine is adapted for intramuscular injection.
11. A method for protecting a pig against Streptococcus suis, Escherichia coli and Clostridium comprising administering the vaccine of claim 1 to the pig.
12. A method for protecting a piglet against a pathogenic infection with Streptococcus suis, Escherichia coli and Clostridium , comprising administering the vaccine of claim 1 to a female pig in order to protect the piglet against a pathogenic infection with Streptococcus suis through the intake by the piglet of colostrum from the female pig following said administering of the vaccine to the female pig.
13. A kit of parts comprising multiple separate vaccine containers, one of which comprises an immunologically effective amount of a Streptococcus suis IgM protease antigen, and one or more additional containers in combination comprise an immunologically effective amount of an Escherichia coli fimbrial antigen, and an immunologically effective amount of a Clostridium toxoid.
14. A method for protecting an animal against Streptococcus suis infection, Escherichia coli infection and Clostridium infection, comprising administering a vaccine comprising an immunologically effective amount of a Streptococcus suis IgM protease antigen;
wherein the IgM protease antigen is mixed with an immunologically effective amount of an Escherichia coli fimbrial antigen, and an immunologically effective amount of a Clostridium toxoid, before administration of the vaccine.