Aqueous oral care solutions, methods, kits, and tooth surfaces having a coating derived from the oral care solution
An aqueous oral care solution, a kit that includes such solution, a method of making such solution, a method of using such solution (e.g., a method of providing fluoride to a patient's tooth surface), and a tooth surface having a coating derived from the aqueous oral care solution, wherein the oral care solution includes: silver cations; thiocyanatc anions provided by a thiocyanatc source comprising Ca(SCN)2; fluoride anions; and water; wherein the molar ratio of silver to thiocyanatc ions is up to 0.40:1, and water is up to 57 wt-%, based on the total weight of the solution.
1. An aqueous oral care solution comprising:
silver cations;
thiocyanate anions provided by a thiocyanate source comprising Ca(SCN) 2 ; fluoride anions; and
water in an amount of up to 57 wt-%, based on the total weight of the solution;
wherein the molar ratio of silver to thiocyanate ions is up to 0.40:1.
2. The oral care solution of claim 1 comprising:
12.5-20.2 wt-% silver cations; and
1.0-6.0 wt-% fluoride anions;
wherein the weight percentages are based on the total weight of the solution;
wherein the molar ratio of silver to thiocyanate ions is at least 0.10:1 and up to 0.40:1; and
wherein the oral care solution forms a precipitate upon contact with additional water or saliva.
3. The oral care solution of claim 2 comprising:
12.5-20.2 wt-% silver cations; and
2.2-3.5 wt-% fluoride anions.
4. The oral care solution of claim 1 , comprising 1-55 wt-% Ca(SCN) 2 .
5. The oral care solution of claim 1 , comprising a source of silver cations selected from silver fluoride, silver chloride, silver nitrate, silver diamine fluoride, and combinations thereof.
6. The oral care solution of claim 1 , comprising a source of fluoride anions selected from silver fluoride, silver diamine fluoride, sodium fluoride, ammonium fluoride, potassium fluoride, amine fluoride, and combinations thereof.
7. The oral care solution of claim 1 , comprising a secondary source of thiocyanate anions selected from ammonium thiocyanate, sodium thiocyanate, potassium thiocyanate, guanidinium thiocyanate, and combinations thereof.
8. The oral care solution of claim 1 , further comprising a thickener.
9. The oral care solution of claim 1 , which has a pH of 5.5 to 9.
10. The oral care solution of claim 1 , comprising less than 5 wt-% organic solvent.
11. The oral care solution of claim 1 , comprising at least 20 wt-% water, based on the total weight of the solution.
12. The oral care solution of any of claim 1 , further comprising one or more active agents.
13. The oral care solution of claim 1 , further comprising calcium cations.
14. The oral care solution of claim 1 , further comprising a surfactant.
15. The oral care solution of claim 1 , which does not stain teeth.
16. A method of providing fluoride to a patient's tooth surface, the method comprising applying the aqueous oral care solution of claim 1 , to the patient's tooth surface.
17. A method of reducing the incidence of dental caries in a patient in need thereof, the method comprising applying an aqueous oral care solution of claim 1 , to the patient's tooth surface.
18. A method of reducing dentin sensitivity and/or root sensitivity in a patient in need thereof, the method comprising applying an aqueous oral care solution of claim 1 , to the patient's tooth surface.
19. A kit comprising an aqueous oral care solution of claim 1 , and an applicator.