METHOD FOR ACQUIRING AUXILIARY INFORMATION
The present invention provides a method for acquiring auxiliary information useful to assist a diagnosis or treatment of prostate cancer. The method for acquiring auxiliary information of the present invention is a method for acquiring auxiliary information to assist a diagnosis or treatment of prostate cancer, and includes a step (C) of dividing a concentration value of a prostate specific antigen having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain, contained in a sample derived from a living body, by a volume value of prostate of the living body to calculate the concentration value of the GalNAc-PSA per prostate volume.
1 . A method for acquiring auxiliary information to assist a diagnosis or treatment of prostate cancer comprising a following (C),
(C): dividing a concentration value of a prostate specific antigen (GalNAc-PSA) having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain, contained in a sample derived from a living body, by a volume value of prostate of the living body to calculate a value (G-PSA density (G-PSAD)) of the concentration of the GalNAc-PSA per prostate volume.
2 . The method for acquiring auxiliary information according to claim 1 , further comprising following (A) and (B),
(A): acquiring the concentration value of the prostate specific antigen (GalNAc-PSA) having the β-N-acetylgalactosamine residue at the non-reducing terminal of the sugar chain contained in the sample derived from the living body, and
(B): acquiring the volume value of the prostate of the living body.
3 . The method for acquiring auxiliary information according to claim 1 , further comprising
(D) classifying calculated G-PSAD values into two or more groups according to magnitudes of the values.
4 . The method for acquiring auxiliary information according to claim 3 , wherein
the (D) is classifying the calculated G-PSAD values into three groups according to magnitudes of the values.
5 . The method for acquiring auxiliary information according to claim 1 , further comprising
(α) acquiring a concentration value of a total prostate specific antigen (total PSA) contained in the sample derived from the living body.
6 . The method for acquiring auxiliary information according to claim 1 , wherein
the concentration value of the total prostate specific antigen (total PSA) in the sample derived from the living body is more than 0 and equal to or less than 100 ng/ml.
7 . The method for acquiring auxiliary information according to claim 1 , wherein
the concentration value of the total prostate specific antigen (total PSA) in the sample derived from the living body is 2 to 20 ng/ml.
8 . The method for acquiring auxiliary information according to claim 2 , wherein
the (A) is acquiring the concentration value of the GalNAc-PSA by an interaction between a molecule having an affinity for the β-N-acetylgalactosamine residue and the GalNAc-PSA.
9 . The method for acquiring auxiliary information according to claim 8 , wherein
the molecule having the affinity for the β-N-acetylgalactosamine residue is Wisteria floribunda lectin (WFA), soybean agglutinin (SBA), Vicia Villosa lectin (VVL), Trichosanthes japonica agglutinin-II (TJA-II), or an anti-β-N-acetylgalactosamine antibody.
10 . The method for acquiring auxiliary information according to claim 2 , wherein
the (A) is measuring the concentration value of the GalNAc-PSA by surface plasmon-field enhanced fluorescence spectroscopy.
11 . An auxiliary information acquisition system comprising: an input device; and an information processing device,
wherein the input device is a device that inputs a concentration value of a GalNAc-PSA in a sample derived from a living body and a volume value of prostate of the living body, and
the information processing device is a device that analyzes probability data for having prostate cancer based on information including a result obtained by dividing the concentration value of the GalNAc-PSA by the volume value of the prostate to calculate a value (G-PSA density (G-PSAD)) of the concentration of the GalNAc-PSA per prostate unit volume,
the acquisition system performing the method for acquiring auxiliary information according to claim 1 .
12 . A non-transitory recording medium storing a computer readable program that causes a computer to execute the acquisition method according to claim 1 .
13 . The method for acquiring auxiliary information according to claim 2 , further comprising
(D) classifying calculated G-PSAD values into two or more groups according to magnitudes of the values.
14 . The method for acquiring auxiliary information according to claim 2 , further comprising
(α) acquiring a concentration value of a total prostate specific antigen (total PSA) contained in the sample derived from the living body.
15 . The method for acquiring auxiliary information according to claim 2 , wherein
the concentration value of the total prostate specific antigen (total PSA) in the sample derived from the living body is more than 0 and equal to or less than 100 ng/ml.
16 . The method for acquiring auxiliary information according to claim 2 , wherein
the concentration value of the total prostate specific antigen (total PSA) in the sample derived from the living body is 2 to 20 ng/ml.
17 . An auxiliary information acquisition system comprising: an input device; and an information processing device,
wherein the input device is a device that inputs a concentration value of a GalNAc-PSA in a sample derived from a living body and a volume value of prostate of the living body, and
the information processing device is a device that analyzes probability data for having prostate cancer based on information including a result obtained by dividing the concentration value of the GalNAc-PSA by the volume value of the prostate to calculate a value (G-PSA density (G-PSAD)) of the concentration of the GalNAc-PSA per prostate unit volume,
the acquisition system performing the method for acquiring auxiliary information according to claim 2 .
18 . A non-transitory recording medium storing a computer readable program that causes a computer to execute the acquisition method according to claim 2 .
19 . The method for acquiring auxiliary information according to claim 3 , further comprising
(α) acquiring a concentration value of a total prostate specific antigen (total PSA) contained in the sample derived from the living body.
20 . The method for acquiring auxiliary information according to claim 3 , wherein
the concentration value of the total prostate specific antigen (total PSA) in the sample derived from the living body is more than 0 and equal to or less than 100 ng/ml.