METHODS FOR THE TREATMENT OF NEUROFIBROMATOSIS
The invention relates to a PI3K inhibitor for use in the treatment of neurofibromatosis type 1 and type 2 in a subject in need thereof. Currently there are no treatment of neurofibromatosis type 1 and 2. Patients mainly received supportive care to treat severe symptoms including surgery to remove tumors compressing nearby tissue or damaging organs, stereotactic radiosurgery or cochlear implants. Inventors have worked on immortalized NF1−/− cells and shown that PIK3CA pharmacological inhibition (BYL719) was associated with increased apoptosis as assessed by PARP cleavage in a dose dependent manner. They also decided to expose NF1−/− cells to a multitargeted therapy including BYL719+selumetinib or BYL719+selumetinib+IPA-3. Importantly, they found that both combinations led to severe apoptosis with double strand DNA break as assessed by the phosphorylation of H2aX. This new approach with either BYL719 alone or in combination with other therapeutics seem to be very promising in patients with neurofibromatosis.
1 . A method for treating neurofibromatosis type 1 and type 2 in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a PI3K inhibitor.
2 . The method according to claim 1 , further comprising administering, simultaneously, separately or sequentially, at least one inhibitor selected from the group consisting of: a MAPK inhibitor, a PAK inhibitor, an mTOR inhibitor, a TK inhibitor, a PARP inhibitor an EGFR inhibitor.
3 . The method according to claim 1 , wherein, the PI3K inhibitor is BYL719 (Alpelisib).
4 . The method according to claim 1 , wherein the PI3K inhibitor is formulated for oral, cutaneous or topical use.
5 . The method according to claim 1 , wherein the PI3K inhibitor is administered as part of a multi-therapy.
6 . (canceled)
7 . A pharmaceutical composition comprising a PI3K inhibitor and at least one inhibitor selected from the group consisting of: a MAPK inhibitor, a PAK inhibitor, an mTOR inhibitor, a TK inhibitor, a PARP inhibitor and an EGFR inhibitor.
8 . (canceled)
9 . The pharmaceutical composition according to claim 7 , wherein the PI3K inhibitor is BYL719 (Alpelisib).
10 . (canceled)