Optimized cage systems promoting bone repair and fusion
This invention provides, inter alia, a device having a cage having an opening or window in at least one of its walls that allows for the insertion of bone growth promoting materials therethrough, comprising one or more openings in one or more of the walls of the cage, designed to receive bone growth promoting materials, including coral-based materials, which facilitate in the fusion with the treated bone, and which optionally serves to reinforce the stability of the implanted structure. Methods of stabilizing two skeletal structures relative to one another, joining two skeletal structures which are discontinuous and repairing a ligament tear or replacing a ligament making use of a bone fusion device of the invention are described.
1. An intervertebral fusion device adapted to form a rigid structure between a first vertebra and a second vertebra, the intervertebral fusion device comprising:
a cage frame defined by a plurality of cage frame elements including a top cage frame element sized and configured to engage the first vertebra, a bottom cage frame element sized and configured to engage the second vertebra, an anterior cage frame element, a posterior cage frame element, and one or more lateral cage frame elements, the top cage frame element adapted to be load bearing for the first vertebra, the bottom cage frame element adapted to be load bearing for the second vertebra; the posterior cage frame element including an opening to receive a bone growth promoting material;
each of the plurality of cage frame elements having a peripheral edge contoured to not be sharp along its entire length;
at least one of the top and bottom cage frame elements includes a plurality of ridges to engage a surface of an adjacent vertebrae, and the ridges are spaced from peripheral edges of the cage frame element;
a bone growth promoting material disposed within the cage frame through said opening of the posterior cage frame element, the bone growth promoting material comprising:
a solid block having a shape complementary to an internal chamber of the cage frame, the solid block having an outer surface; and
a plurality of grooves formed within the outer surface, at least some of the plurality of grooves complementary to and adapted to accommodate at least some of the plurality of cage frame elements therein such that the outer surface of the bone growth promoting material is neither protruding nor recessed with respect to at least some of the plurality of cage frame elements;
wherein the bone growth promoting material comprises one or more solid coral pieces, or ground coralline-based material pieces or a combination thereof,
wherein the bone growth promoting material is characterized by a specific fluid uptake capacity value of at least 75%.
2. The intervertebral fusion device of claim 1 , wherein the cage includes a memory metal.
3. The intervertebral fusion device of claim 1 , wherein the cage is adapted to form a modular component.
4. The intervertebral fusion device of claim 1 , wherein the cage is adapted to be stackable with at least another cage.
5. The intervertebral fusion device of claim 1 , wherein the cage comprises stainless steel, titanium, chrome, cobalt, polycarbonate, polypropylene, polyethylene, polymethylmethacrylate, polysulfone filled with glass or carbon fibers, nitinol, PEEK, a ceramic material, hydroxyapatite coated hard materials or a combination thereof.
6. The intervertebral fusion device of claim 1 , wherein the coralline-based material is an enriched coralline-based material that is enriched for silicium.
7. The intervertebral fusion device of claim 1 , wherein the cage frame, the bone growth promoting material or a combination thereof may be prepared according to any geometry suitable to accommodate within a desired site of bone repair or bone joining.
8. The intervertebral fusion device of claim 7 , wherein the geometry is customized based on medical imaging assessments of the site of bone repair or bone joining.
9. The intervertebral fusion device of claim 8 , wherein the medical imaging assessment comprises CT or MRI scanning.
10. The intervertebral fusion device of claim 1 , wherein the bone growth promoting material is isolated from a Porites species, a Goniopora , a Millepora species or an Acropora species.
11. A method for stabilizing a first vertebra and a second vertebra relative to one another, the method comprising:
disposing the intervertebral fusion device of claim 1 between the first and second vertebrae; and
securing the intervertebral fusion device between the first and second vertebrae to inhibit movement of the first and second vertebrae relative to one another, even when the first and second vertebrae are subject to forces other than perpendicular compressive forces.