TOPICAL ANTIMICROBIAL MICROEMULSIONS WITH FLUORESCENT MATERIALS
A topical antimicrobial composition includes a lipophilic component including a surfactant system with an HLB value of less than 10; an amphiphilic component including an antimicrobial compound; an aqueous hydrophilic component; and a fluorescent material. The composition includes less than 10 wt % of lower monohydric alcohols based on the total weight of the composition. The composition is in the form of a microemulsion at room temperature with a disperse phase having droplets with a particle size of 5 nm to 400 nm.
1 . A topical antimicrobial composition, comprising:
a lipophilic component comprising a surfactant system with an HLB value of less than about 10;
an amphiphilic component comprising an antimicrobial compound;
an aqueous hydrophilic component; and
a fluorescent material;
wherein the composition comprises less than about 10 wt % of lower monohydric alcohols, based on the total weight of the composition, and wherein the composition is in the form of a microemulsion at room temperature with a disperse phase having droplets with a particle size of about 5 nm to about 400 nm.
2 . The topical antimicrobial composition of claim 1 , wherein the fluorescent material comprises a fluorescent dye with an absorption peak in the ultraviolet and violet portion of the electromagnetic spectrum (340-370 nm) with a corresponding emission peak in the visible portion of the spectrum (400-750 nm).
3 . The topical antimicrobial composition of claim 2 , wherein the fluorescent dye has an emission peak in the blue region of the visible spectrum (420-470 nm), and the emission peak is observable with an ultraviolet (UV) lamp.
4 . The topical antimicrobial composition of claim 1 , wherein the fluorescent material comprises a fluorescent dye with an emission peak in the near infrared (IR) region of the spectrum (780 nm to 2500 nm), and the emission peak is observable with an IR camera.
5 . The topical antimicrobial composition of claim 1 , wherein the fluorescent material comprises a fluorescent dye chosen from stilbene compounds, coumarin derivatives, diaryldipyrazoline derivatives, naphthalimide derivatives, benzoxazole derivatives, pyrazoline derivatives, cationic benzimidazole derivatives, hexasodium-2,2′-[vinylenebis[3-sulfonato-4,1-phenylene)imino[6-(diethylamino)-1,3,5-triazine-4,2-diyl]imino]]bis(benzene-1,4-disulphonate), curcuminoids, and mixtures and combinations thereof.
6 . The topical antimicrobial composition of claim 1 , wherein the fluorescent material comprises a fluorescent dye present at about 0.001 wt % to about 10 wt %, based on the total weight of the composition.
7 . The topical antimicrobial composition of claim 1 , wherein the composition further comprises a visible dye with an absorption and transmission peak in the visible region of the electromagnetic spectrum (400-700 nm).
8 . (canceled)
9 . The topical antimicrobial composition of claim 1 , wherein the composition comprises less than about 5% of lower monohydric alcohols.
10 . The topical antimicrobial composition of claim 1 , wherein the composition has no closed cup flash point at temperatures of 70° F. to 200° F. as measured according to ASTM D-3278-96 e-1.
11 . The topical antimicrobial composition of claim 1 , wherein the composition provides at least a 1.5-log microbial reduction on mammalian skin following 10 minute contact as measured according to ASTM E1874-09.
12 . The topical antimicrobial composition of claim 1 , wherein the aqueous hydrophilic component is present in an amount of about 5 wt % to about 98 wt %, based on the total weight of the composition.
13 . The topical antimicrobial composition of claim 1 , wherein the aqueous hydrophilic component comprises at least about 80 wt % water, based on the total weight of the aqueous hydrophilic component.
14 . The antimicrobial composition of claim 1 , wherein the lipophilic component is present in the composition at about 0.5 wt % to about 50 wt %, based on the total weight of the composition.
15 . The topical antimicrobial composition of claim 1 , wherein the lipophilic component is chosen from esters, ethers, amides, glycols, monoalkyl and monoalkylene alcohols with greater than 7 carbons atoms and less than 18 carbon atoms, liquid paraffins, liquid waxes, and mixtures and combinations thereof.
16 . The topical antimicrobial composition of claim 1 , wherein the amphiphilic component is present in the composition at about 0.05 wt % to about 40 wt %, based on the total weight of the composition.
17 . The topical antimicrobial composition of claim 1 , wherein the surfactant system comprises an ester of glycerol with a fatty acid.
18 . The topical antimicrobial composition of claim 1 , wherein the antimicrobial compound is chosen from octenidine, biguanides, (bis)biguanides, polymeric biguanides, quaternary ammonium salts, and mixtures and combinations thereof.
19 . The topical antimicrobial composition of claim 1 , wherein the antimicrobial compound is present in the composition at about 0.05% by weight to about 10% by weight, based on the total weight of the composition.
20 . A method of disinfecting mammalian skin, the method comprising:
applying to the mammalian skin the topical antiseptic composition of claim 1 .
21 . A kit, comprising:
the topical mammalian tissue antiseptic composition of claim 1 ; and
an applicator for applying the antiseptic composition to skin of a patient.