Biopharmaceutical liquid reservoir with mechanical member including rotating and stationary sets of parts

1. A biopharmaceutical liquid vessel, comprising:

a bag forming an inner storage space for storing biopharmaceutical liquid,

a mechanical member located at a wall of the bag, comprising:

a set of stationary parts, stationary with respect to the wall of the bag,

a set of rotating parts, rotating about an axis of rotation with respect to the set of stationary parts,

a bearing located between the set of stationary parts and the set of rotating parts and in an inner storage space inside the bag,

a communication passage separating the bearing of the inner storage space, comprising one or more changes of direction being formed by a portion of the parts of the set of rotating parts located opposite a portion of the parts of the set of stationary parts.

2. The biopharmaceutical liquid vessel according to claim 1 , wherein the passage forms an inverted siphon, of the air being trapped in a bottom of the inverted siphon by the liquid located at least in one branch of the inverted siphon starting at the bottom of the inverted siphon and opening into the inner storage space.

3. The biopharmaceutical liquid vessel according to claim 2 , wherein said air being trapped in the bottom of the inverted siphon by the liquid located at least in two branches of the at least one branch of the inverted siphon, a first branch of the two branches starting at the bottom of the inverted siphon and opening into the inner storage space and a second branch of the two branches starting at the bottom of the inverted siphon and going up to the bearing.

4. The biopharmaceutical liquid vessel according to claim 2 , wherein the bearing is an only contact zone between the set of rotating parts and the set of stationary parts.

5. The biopharmaceutical liquid vessel according to claim 1 , wherein the communication passage travels mainly between a cap of the set of rotating parts and a containment of the set of stationary parts, the cap rotating about the axis of rotation with respect to the containment, the cap and the containment being nested at least partially in one another to form the communication passage.

6. The biopharmaceutical liquid vessel according to claim 1 , wherein the set of stationary parts or the set of rotating parts forms a projection entering into a cavity of the other set, the communication passage bypassing the projection by traveling along the walls of the cavity.

7. The biopharmaceutical liquid vessel according to claim 6 , wherein the set of rotating parts forms the cavity and the set of stationary parts forms the projection.

8. The biopharmaceutical liquid vessel according to claim 1 , wherein the communication passage is a passage having a symmetry of revolution about the axis of rotation.

9. The biopharmaceutical liquid vessel according to claim 1 , wherein the width of the communication passage in a plane containing the axis of rotation is comprised between 0.5 mm and 5 mm.

10. The biopharmaceutical liquid vessel according to claim 1 , wherein the communication passage comprises at least two passages parallel to the axis of rotation, separated by a bend.

11. The biopharmaceutical liquid vessel according to claim 10 , wherein one of the passages parallel to the axis of rotation connects the bend to a cavity comprising the bearing.

12. The biopharmaceutical liquid vessel according to claim 1 , wherein the communication passage comprises radial fins regularly distributed about the axis of rotation, located in the branch of the inverted siphon starting at the bottom of the inverted siphon and opening into the inner storage space.

13. The biopharmaceutical liquid vessel according to claim 12 , wherein the radial fins extend from the outer face of the inner wall of a portion of the set of stationary parts.

14. The biopharmaceutical liquid vessel according to claim 12 , wherein the radial fins extend in an inclined manner with respect to a wall inside the communication passage, the direction of the inclination being such as given from the direction of rotation of the set of rotating parts around the set of stationary parts of possible solid particles located in the communication passage remain retained or blocked between the fins and said wall inside the communication passage.

15. The biopharmaceutical liquid vessel according to claim 1 , wherein the bearing is an only support zone of the set of rotating parts by the set of stationary parts.

16. The biopharmaceutical liquid vessel according to claim 1 , wherein the bearing is a ball bearing.

17. The biopharmaceutical liquid vessel according to claim 1 , wherein the mechanical member passes through the wall of the bag at an opening of the wall of the bag.

18. The biopharmaceutical liquid vessel according to claim 17 , wherein the opening of the wall of the bag is fastened in a sealed manner around the mechanical member.

19. The biopharmaceutical liquid vessel according to claim 18 , wherein the opening is welded or glued around the set of stationary parts.

20. The biopharmaceutical liquid vessel according to claim 1 , wherein the set of rotating parts carries a rotating shaft.

21. The biopharmaceutical liquid vessel according to claim 20 , wherein the rotating shaft carries a propeller.

22. The biopharmaceutical liquid vessel according to claim 1 , wherein set of stationary parts comprises a draining port opening to an outside of the bag.

23. The biopharmaceutical liquid vessel according to claim 1 , wherein a gas distributor is located around the set of stationary parts and the set of rotating parts, in the inner storage space.

24. The biopharmaceutical liquid vessel according to claim 23 , wherein the gas distributor is annular.

25. The biopharmaceutical liquid vessel according to claim 23 , wherein the gas distributor comprises at least one diversion capable of blowing air into the communication passage so as to tend to make the air emerge in the inner storage space.

26. The biopharmaceutical liquid vessel according to claim 1 , wherein the set of rotating parts comprises an intermediate connecting part carrying the rotating shaft and the bearing.

27. The biopharmaceutical liquid vessel according to claim 26 , wherein the rotating shaft is clipped in the intermediate connecting part.

28. The biopharmaceutical liquid vessel according to claim 26 , wherein the bearing comprises an outer ring, said outer ring clipped in the intermediate connecting part.

29. The biopharmaceutical liquid vessel according to claim 26 , wherein the intermediate connecting part carries the rotating cap which is clipped on this intermediate connecting part.

30. The biopharmaceutical liquid vessel according to claim 1 , wherein the stationary set comprises a base which carries the bearing, and which has a draining port opening to an outside of the inner storage space.

31. The biopharmaceutical liquid vessel according to claim 30 , wherein the gas distributor is clipped around the base.

32. The biopharmaceutical liquid vessel according to claim 30 , wherein the bearing is clipped around the base.

33. The biopharmaceutical liquid vessel according to claim 30 , wherein the bearing comprises a stationary inner ring, said inner ring maintaining the containment blocked against the base.

34. The biopharmaceutical liquid vessel according to claim 1 , wherein the biopharmaceutical liquid comprises inert micro-supports, of which the largest dimension is less than 0.3 mm cells fastened to these micro-supports.

35. The biopharmaceutical liquid vessel according to claim 34 , wherein the micro-supports are balls.

36. The biopharmaceutical liquid vessel according to claim 1 , wherein most of the parts of the set of stationary parts and the set of rotating parts are made of rigid plastic, slightly deformable so as to be able to carry out an operation of clipping to one another.

37. The biopharmaceutical liquid vessel according to claim 1 , wherein the wall of the bag is made of material, sufficiently flexible and deformable to be able to be folded.